Evidence map›Paper›PMID 21808142›Full record

ArticleThe Indian journal of medical research2011

Preliminary studies on CD36 gene in type 2 diabetic patients from north India.

Sunaina Gautam, C G Agrawal, Hemant Kumar Bid, Monisha Banerjee

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Article in The Indian journal of medical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. [CD36 gene deletion reduces muscle insulin sensitivity in mice by up-regulating PTP1B expression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sunaina GautamDepartment of Zoology, University of Lucknow, Lucknow, India.
C G Agrawal
Hemant Kumar Bid
Monisha Banerjee
University of Lucknow · INCentral Drug Research Institute · INKing George's Medical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesThe greater tendency to diabetes in Indians may be due to genetic factors in addition to environment and diet. CD36, a class B scavenger cell surface receptor mediates internalization of oxidized low density lipoprotein (Ox-LDL) leading to the formation of macrophage foam cells. CD36 deficiency is related to phenotypic expression of the metabolic syndrome, frequently associated with atherosclerotic cardiovascular diseases resulting in raised levels of glucose thereby contributing to type 2 diabetes (T2DM). Therefore, the association of human CD36 gene mutation to T2DM needs investigation. We undertook this study to investigate CD36 gene status in north Indian subjects by screening for the deletion of exons 3, 4 and 5 and certain polymorphisms.

methodsClinical characteristics were compared between 300 T2DM patients and 100 healthy controls. Deletion analysis was carried out for exons 3, 4 and 5 of CD36 gene in 300 T2DM patients using PCR and agarose gel electrophoresis. Genotype analysis for two polymorphisms 478C>T and delAC in exons 4 and 5 respectively was carried out using PCR-RFLP method.

resultsBiochemical parameters such as fasting and post-prandial glucose levels, total cholesterol, LDL-cholesterol and blood pressure were slightly raised in the T2DM patients when compared with controls with lowered HDL-cholesterol. No exonic deletion was observed in the 300 patients and 100 controls screened. All individuals were found to be homozygous (CC and -/-) for the two polymorphisms studied. INTERPRETATION &

conclusionsAlthough no exonic deletion was found in T2DM patients, our study suggests that all 15 exons need to be screened for mutations which lead to CD36 deficiency. Genotyping studies of the two SNPs in the CD36 gene confirmed the absence of exons 4 and 5 deletion. This is perhaps the first report from India suggesting that CD36 is one of the several important genes that need to be explored in relation to T2DM.

Indexed as

AdultBlood GlucoseBlood PressureCD36 AntigensCholesterol, LDLDiabetes Mellitus, Type 2ExonsFemaleGenetic Association StudiesGenotypeHumansIndiaMaleMiddle AgedPolymorphism, Single NucleotideSequence DeletionBlood GlucoseCD36 AntigensCholesterol, LDL

Identifiers

PMID21808142
PMCPMC3171903
OpenAlexW2139432802

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.