ArticleProceedings of the National Academy of Sciences of the United States of America2011
Homogeneous catalytic O2 reduction to water by a cytochrome c oxidase model with trapping of intermediates and mechanistic insights.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 113 citations in OpenAlex.
- Breaking the Linear Scaling Relations for the Oxygen Reduction Reaction with a Dual-Atom Catalyst Composed of a MnFe-Porphyrrole Aerogel.Angewandte Chemie (International ed. in English) · 2025Article
- Bridging oxidase catalysis and oxygen reduction electrocatalysis by model single-atom catalysts.National science review · 2022Article
- Review
- Recent Progress of Electrochemical Production of Hydrogen Peroxide by Two-Electron Oxygen Reduction Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Molecular understanding of heteronuclear active sites in heme-copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling.Chemical Society reviews · 2021Review
- Structural Determination of an Unusual CuChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Selectivity-Determining Steps in OJournal of the American Chemical Society · 2020Article
- Spin Interconversion of Heme-Peroxo-Copper Complexes Facilitated by Intramolecular Hydrogen-Bonding Interactions.Journal of the American Chemical Society · 2019Article
- Influence of intramolecular secondary sphere hydrogen-bonding interactions on cytochromeChemical science · 2019Article
- Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function.Chemical reviews · 2018Review
- Conducting Copper(I/II)-Metallopolymer for the Electrocatalytic Oxygen Reduction Reaction (ORR) with High Kinetic Current Density.Polymers · 2018Article
- Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins.Chemical reviews · 2018Review
- A water-soluble supramolecular complex that mimics the heme/copper hetero-binuclear site of cytochromeChemical science · 2018Article
- A High-Valent Non-Heme μ-Oxo Manganese(IV) Dimer Generated from a Thiolate-Bound Manganese(II) Complex and Dioxygen.Angewandte Chemie (International ed. in English) · 2017Article
- Critical Aspects of Heme-Peroxo-Cu Complex Structure and Nature of Proton Source Dictate Metal-O(peroxo) Breakage versus Reductive O-O Cleavage Chemistry.Journal of the American Chemical Society · 2017Article
- Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Catalytic two-electron reduction of dioxygen catalysed by metal-free [14]triphyrin(2.1.1).Chemical science · 2015Article
- Electrocatalytic O2-Reduction by Synthetic Cytochrome c Oxidase Mimics: Identification of a "Bridging Peroxo" Intermediate Involved in Facile 4e(-)/4H(+) O2-Reduction.Journal of the American Chemical Society · 2015Article
- Lewis acid-induced change from four- to two-electron reduction of dioxygen catalyzed by copper complexes using scandium triflate.Journal of the American Chemical Society · 2015Article
- Nitric oxide generation from heme/copper assembly mediated nitrite reductase activity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
An efficient and selective four-electron plus four-proton (4e(-)/4H(+)) reduction of O(2) to water by decamethylferrocene and trifluoroacetic acid can be catalyzed by a synthetic analog of the heme a(3)/Cu(B) site in cytochrome c oxidase ((6)LFeCu) or its Cu-free version ((6)LFe) in acetone. A detailed mechanistic-kinetic study on the homogeneous catalytic system reveals spectroscopically detectable intermediates and that the rate-determining step changes from the O(2)-binding process at 25 °C room temperature (RT) to the O-O bond cleavage of a newly observed Fe(III)-OOH species at lower temperature (-60 °C). At RT, the rate of O(2)-binding to (6)LFeCu is significantly faster than that for (6)LFe, whereas the rates of the O-O bond cleavage of the Fe(III)-OOH species observed (-60 °C) with either the (6)LFeCu or (6)LFe catalyst are nearly the same. Thus, the role of the Cu ion is to assist the heme and lead to faster O(2)-binding at RT. However, the proximate Cu ion has no effect on the O-O bond cleavage of the Fe(III)-OOH species at low temperature.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.