ArticleProceedings of the National Academy of Sciences of the United States of America2011
High-speed microscopic imaging of flagella motility and swimming in Giardia lamblia trophozoites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- The cytoskeleton of pathogenic protists.Bioscience reports · 2026Review
- A novel mechanism of microbial attachment: The flagellar pump ofPNAS nexus · 2024Article
- Characterization of a unique attachment organelle: Single-cell force spectroscopy ofNanoscale · 2024Article
- Ultrastructural Alterations of the Human PathogenPathogens (Basel, Switzerland) · 2023Review
- Unusual Cell Structures and Organelles inMicroorganisms · 2022Review
- The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment.PLoS pathogens · 2022Article
- Identification of Actin Filament-Associated Proteins in Giardia lamblia.Microbiology spectrum · 2021Article
- Multifocal imaging for precise, label-free tracking of fast biological processes in 3D.Nature communications · 2021Article
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- Nek8445, a protein kinase required for microtubule regulation and cytokinesis inMolecular biology of the cell · 2020Article
- Microtubule organelles in Giardia.Advances in parasitology · 2020Review
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- Article
- Multiple paralogues of α-SNAP in Giardia lamblia exhibit independent subcellular localization and redistribution during encystation and stress.Parasites & vectors · 2018Article
- Hybrid Structured Illumination Expansion Microscopy Reveals Microbial Cytoskeleton Organization.ACS nano · 2017Article
- Myosin-independent cytokinesis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microtubule teardrop patterns.Scientific reports · 2015Article
- Advances in understanding Giardia: determinants and mechanisms of chronic sequelae.F1000prime reports · 2015Review
- Unlocking the secrets of multi-flagellated propulsion: drawing insights from Tritrichomonas foetus.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report, in this paper, several findings about the swimming and attachment mechanisms of Giardia lamblia trophozoites. These data were collected using a combination of a high-contrast CytoViva imaging system and a particle image velocimetry camera, which can capture images at speeds greater than 800 frames/s. Using this system, we discovered that, during rapid swimming of Giardia trophozoites, undulations of the caudal region contributed to forward propulsion combined with the beating of the flagella pairs. It was also discovered, in contrast to previous studies with 10 times slower image sampling technique, that the anterior and posterolateral flagella beat with a clearly defined power stroke and not symmetrical undulations. During the transition from free swimming to attachment, trophozoites modified their swimming behavior from a rapid rotating motion to a more stable planar swimming. While using this planar swimming motion, the trophozoites used the flagella for propulsion and directional control. In addition to examination of the posterolateral and anterior flagella, a model to describe the motion of the ventral flagella was derived, indicating that the ventral flagella beat in an expanding sine wave. In addition, the structure of the ventrocaudal groove creates boundary conditions that determine the form of beating of the ventral flagella. The results from this study indicate that Giardia is able to simultaneously generate both ciliary beating and typical eukaryotic flagellar beating using different pairs of flagella.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.