ArticleMolecular cancer research : MCR2011
Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer.
Article in Molecular cancer research : MCR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 22 citations in OpenAlex.
- Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer.PloS one · 2018Article
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- Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.Molecular cancer research : MCR · 2017Article
- Recombinant cells in the lung increase with age via de novo recombination events and clonal expansion.Environmental and molecular mutagenesis · 2017Article
- Epithelial cell migration as a potential therapeutic target in early lung cancer.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis.Cancer research · 2015Article
- Statistical thermodynamics of transcription profiles in normal development and tumorigeneses in cohorts of patients.European biophysics journal : EBJ · 2015Article
- CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.Cancer research · 2015Article
- Article
- Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver.Oncotarget · 2014Article
- Lung tumourigenesis in a conditional Cul4A transgenic mouse model.The Journal of pathology · 2014Article
- Systems biology approaches to develop innovative strategies for lung cancer therapy.Cell death & disease · 2014Review
- Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.Cell · 2014Article
- Article
- The genetics and biology of KRAS in lung cancer.Chinese journal of cancer · 2013Review
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the Kras(LA2) model of lung cancer. Copy number gain involving the Kras locus, as focal amplification or whole chromosome gain, is the most common alteration in these tumors and with a prevalence that increased significantly with increasing tumor size. Furthermore, Kras amplification was the only major genomic event among the smallest lung tumors, suggesting that this alteration occurs early during the development of mutant Kras-driven lung cancers. Recurring gains and deletions of other chromosomes occur progressively more frequently among larger tumors. These results are in contrast to a previous aCGH analysis of lung tumors from Kras(LA2) mice on a mixed genetic background, in which relatively few DNA copy number alterations were observed regardless of tumor size. Our model features the Kras(LA2) allele on the inbred FVB/N mouse strain, and in this genetic background, there is a highly statistically significant increase in level of genomic instability with increasing tumor size. These data suggest that recurring DNA copy alterations are important for tumor progression in the Kras(LA2) model of lung cancer and that the requirement for these alterations may be dependent on the genetic background of the mouse strain.
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