Trial reportJournal of the American Society of Nephrology : JASN2011
Dipstick proteinuria as a screening strategy to identify rapid renal decline.
Trial report in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Screening with urinary dipsticks for reducing morbidity and mortality.The Cochrane database of systematic reviews · 2015Pooled it
- Estimated pulse wave velocity and dipstick proteinuria in young adults with MASLD: a cross-sectional health-check analysis.Frontiers in medicine · 2026Article
- Efficacy of screening with dipstick urinalysis in predicting renal function decline in healthy workers: a 10-year follow-up study.Clinical and experimental nephrology · 2025Article
- Waist-to-height ratio and the incidence of rapid kidney function decline and chronic kidney disease: insights from the China health and retirement longitudinal study.BMC nephrology · 2025Article
- Chronic kidney disease.Nature reviews. Disease primers · 2025Review
- Association of decreased estimated glomerular filtration rate with lung cancer risk in the Korean population.Epidemiology and health · 2024Article
- Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein.Biomedicines · 2023Article
- Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study.Scientific reports · 2022Article
- Kidney Injuries and Evolution of Chronic Kidney Diseases Due to Neonatal Hyperoxia Exposure Based on Animal Studies.International journal of molecular sciences · 2022Review
- Clinical and Pathological Features of Chinese Patients with Type 2 Diabetes, Biopsy-Proven Diabetic Kidney Disease, and Rapid eGFR Decline.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- The epidemiology of chronic kidney disease (CKD) in rural East Africa: A population-based study.PloS one · 2020Article
- Isolated proteinuria due to CUBN homozygous mutation - challenging the investigative paradigm.BMC nephrology · 2019Article
- Acute kidney injury in hospitalized patients who underwent percutaneous kidney biopsy for histological diagnosis of their renal disease.BMC nephrology · 2019Article
- Rapid decline of renal function in patients with type 2 diabetes with heavy proteinuria: a report of three cases.BMC nephrology · 2019Article
- Tryptophan as a surrogate prognostic marker for diabetic nephropathy.Journal of diabetes investigation · 2018Article
- The First Report on the Frequency of Asymptomatic Proteinuria in Iranian School-aged Children.Advanced biomedical research · 2018Article
- Interaction of Serum Phosphate with Age as Predictors of Cardiovascular Risk Scores in Stable Renal Transplant Recipients.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Article
- Strategies and cost-effectiveness evaluation of persistent albuminuria screening among high-risk population of chronic kidney disease.BMC nephrology · 2017Article
- Interplay between Diagnostic Criteria and Prognostic Accuracy in Chronic Kidney Disease.PLoS medicine · 2016Article
- When to initiate renal replacement therapy: The trend of dialysis initiation.World journal of nephrology · 2015Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid kidney function decline (RKFD) predicts cardiovascular morbidity and mortality, but serial assessment of estimated GFR (eGFR) is not cost-effective for the general population. Here, we evaluated the predictive value of albuminuria and three thresholds of dipstick proteinuria to identify RKFD in 2,574 participants in a community-based prospective cohort study with a median of 7 years follow-up. Median change in eGFR was -0.78 ml/min per 1.73 m(2) per year; with 8.5% experiencing RKFD, defined as a >5% annual eGFR decline from baseline. Of those with RKFD, 65% advanced to a new CKD stage compared with 19% of those without RKFD. Dipstick protein ≥ 1 g/L was a stronger predictor of RKFD than albuminuria. Overall, 2.5% screened positive for dipstick protein ≥ 1 g/L at baseline; one of every 2.6 patients would have RKFD if all were followed with serial eGFR measurement. Overall, the screening strategy correctly identified progression status for 90.8% of patients, mislabeled 1.5% as RKFD, and missed 7.7% with eventual RKFD. Among those with risk factors (cardiovascular disease, age >60, diabetes, or hypertension), the probability of identifying RKFD from serial eGFR measurements increased from 13 to 44% after incorporating dipstick protein (≥ 1 g/L threshold). In summary, inexpensive screening with urine dipstick should allow primary care physicians to follow fewer patients with serial eGFR assessment but still identify those with rapid decline of kidney function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.