ArticleJournal of leukocyte biology2011
Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes.
Article in Journal of leukocyte biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Beyond traditional anticoagulants: exploring the future of thromboembolism treatment with FXI inhibitors.Frontiers in immunology · 2026Review
- Inhibition of contact-mediated activation of factor XI protects baboons againstBlood advances · 2019Article
- Factor XI and pulmonary infections.Haemophilia : the official journal of the World Federation of Hemophilia · 2018Article
- Factor XII and uPAR upregulate neutrophil functions to influence wound healing.The Journal of clinical investigation · 2018Article
- Factor XI contributes to myocardial ischemia-reperfusion injury in mice.Blood advances · 2018Article
- Biorheology of platelet activation in the bloodstream distal to thrombus formation.Cellular and molecular bioengineering · 2016Article
- Factor XI as a Therapeutic Target.Arteriosclerosis, thrombosis, and vascular biology · 2016Review
- Membrane permeability of the human granulocyte to water, dimethyl sulfoxide, glycerol, propylene glycol and ethylene glycol.Cryobiology · 2014Article
- Article
- Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy.American journal of physiology. Cell physiology · 2013Article
- Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation.American journal of physiology. Cell physiology · 2013Article
- p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.PloS one · 2013Article
- Article
- Development of coagulation factor probes for the identification of procoagulant circulating tumor cells.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
PMN leukocytes are the most abundant leukocytes in the circulation and play an important role in host defense. PMN leukocyte recruitment and inflammatory responses at sites of infection are critical components in innate immunity. Although inflammation and coagulation are known to have bidirectional relationships, little is known about the interaction between PMN leukocytes and coagulation factors. Coagulation FXI participates in the intrinsic coagulation pathway upon its activation, contributing to hemostasis and thrombosis. We have shown previously that FXI-deficient mice have an increased survival and less leukocyte accumulation into the peritoneum in severe polymicrobial peritonitis. This result suggests a role for FXI in leukocyte trafficking and/or function. In this study, we characterized the functional consequences of FXIa binding to PMN leukocytes. FXIa reduced PMN leukocyte chemotaxis triggered by the chemokine, IL-8, or the bacterial-derived peptide, fMLP, perhaps as a result of the loss of directed migration. In summary, our data suggest that FXIa modulates the inflammatory response of PMN leukocytes by altering migration. These studies highlight the interplay between inflammation and coagulation and suggest that FXIa may play a role in innate immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.