Evidence map›Paper›PMID 21807523›Full record

ArticleBioorganic & medicinal chemistry2011

Chromomycin SA analogs from a marine-derived Streptomyces sp.

Youcai Hu, Ana Paula D M Espindola, Nathan A Stewart, Shuguang Wei, Bruce A Posner, John B MacMillan

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Natural Products from Singapore Soil-DerivedMolecules (Basel, Switzerland) · 2023
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Chromomycin AThe Journal of general physiology · 2018
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Youcai HuDepartment of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
Ana Paula D M Espindola
Nathan A Stewart
Shuguang Wei
Bruce A Posner
John B MacMillan
The University of Texas Southwestern Medical Center · US

Funding

Structure guided discovery of small molecule antagonists of Smac (DIABLO)/XIPAP01CA095471 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MCKNIGHT, STEVEN L · 2002 to 2011
$34.1M
Marine Actinomycetes as a Resource for Anticancer Natural ProductsR01CA149833 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MACMILLAN, JOHN B · 2010 to 2014
$1.6M
NCI NIH HHS P01 CA095471NCI NIH HHS P01-CA095471NCI NIH HHS R01 CA149833
6 · The paper itself

Abstract

Two chromomycin SA analogs, chromomycin SA(3) and chromomycin SA(2), along with deacetylchromomycin A(3) and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA(3) and chromomycin SA(2) are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.

Indexed as

Antineoplastic AgentsChromomycinsDrug Screening Assays, AntitumorMagnetic Resonance SpectroscopyMolecular ConformationStreptomycesAntineoplastic AgentsChromomycinschromomycin SA2chromomycin SA3

Identifiers

PMID21807523
PMCPMC3159829
OpenAlexW1988354613

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.