ArticleDrug and alcohol dependence2012
MDMA (Ecstasy) association with impaired fMRI BOLD thalamic coherence and functional connectivity.
Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers.Brain connectivity · 2018Article
- Disentangling Multispectral Functional Connectivity With Wavelets.Frontiers in neuroscience · 2018Article
- Characterization of thalamo-cortical association using amplitude and connectivity of functional MRI in mild traumatic brain injury.Journal of magnetic resonance imaging : JMRI · 2014Article
- Oscillatory serotonin function in depression.Synapse (New York, N.Y.) · 2013Review
- Human ecstasy (MDMA) polydrug users have altered brain activation during semantic processing.Psychopharmacology · 2013Article
- Wavelet-transformed temporal cerebral blood flow signals during attempted inhibition of cue-induced cocaine craving distinguish prognostic phenotypes.Drug and alcohol dependence · 2013Article
- 3,4-methylenedioxymethamphetamine (MDMA): current perspectives.Substance abuse and rehabilitation · 2013Review
- Cocaine, Appetitive Memory and Neural Connectivity.Journal of clinical toxicology · 2012Article
- Evidence for chronically altered serotonin function in the cerebral cortex of female 3,4-methylenedioxymethamphetamine polydrug users.Archives of general psychiatry · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMDMA exposure is associated with chronic serotonergic dysfunction in preclinical and clinical studies. A recent functional magnetic resonance imaging (fMRI) comparison of past MDMA users to non-MDMA-using controls revealed increased spatial extent and amplitude of activation in the supplementary motor area during motor tasks (Karageorgiou et al., 2009). Blood oxygenation level dependent (BOLD) data from that study were reanalyzed for intraregional coherence and for inter-regional temporal correlations between time series, as functional connectivity.
methodsFourteen MDMA users and ten controls reporting similar non-MDMA abuse performed finger taps during fMRI. Fourteen motor pathway regions plus a pontine raphé region were examined. Coherence was expressed as percent of voxels positively correlated with an intraregional index voxel. Functional connectivity was determined using wavelet correlations.
resultsIntraregional thalamic coherence was significantly diminished at low frequencies in MDMA users compared to controls (p=0.009). Inter-regional functional connectivity was significantly weaker for right thalamo - left caudate (p=0.002), right thalamo - left thalamus (p=0.007), right caudate - right postcentral (p=0.007) and right supplementary motor area - right precentral gyrus (p=0.011) region pairs compared to controls. When stratified by lifetime exposure, significant negative associations were observed between cumulative MDMA use and functional connectivity in seven other region-pairs, while only one region-pair showed a positive association.
conclusionsReported prior MDMA use was associated with deficits in BOLD intraregional coherence and inter-regional functional connectivity, even among functionally robust pathways involving motor regions. This suggests that MDMA use is associated with long-lasting effects on brain neurophysiology beyond the cognitive domain.
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