ArticleBiophysical journal2011
Initial dynamics of cell spreading are governed by dissipation in the actin cortex.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces.Biophysical journal · 2022Article
- Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells.PLoS computational biology · 2022Article
- The Entry and Egress of Monocytes in Atherosclerosis: A Biochemical and Biomechanical Driven Process.Cardiovascular therapeutics · 2021Review
- Development of Nascent Focal Adhesions in Spreading Cells.Biophysical journal · 2020Review
- Dynamic microtubules drive fibroblast spreading.Biology open · 2018Article
- Cellular cholesterol regulates monocyte deformation.Journal of biomechanics · 2017Article
- Prediction of traction forces of motile cells.Interface focus · 2016Article
- Cell surface topography is a regulator of molecular interactions during chemokine-induced neutrophil spreading.Biophysical journal · 2014Article
- Three-dimensional cell body shape dictates the onset of traction force generation and growth of focal adhesions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Discoidin domain receptor tyrosine kinases: new players in cancer progression.Cancer metastasis reviews · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initial stages of spreading of a suspended cell onto a substrate under the effect of (specific or nonspecific) adhesion exhibit a universal behavior, which is cell-type independent. We show that this behavior is governed only by cell-scale phenomena. This can be understood if the main retarding force that opposes cell adhesion is of mechanical origin, that is, dissipation occurring during the spreading. By comparing several naive models that generate different patterns of dissipation, we show by numerical simulation that only dissipation due to the deformation of the actin cortex is compatible with the experimental observations. This viscous-like dissipation corresponds to the energetic cost of rearranging the cytoskeleton, and is the trace of all dissipative events occurring in the cell cortex during the early spreading, such as the binding and unbinding of cross-linkers and molecular friction.
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