ArticleBiophysical journal2011
Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Understanding development and cellular plasticity in the pancreas in health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Tipping-point transition from transient to persistent inflammation in pancreatic islets.NPJ systems biology and applications · 2024Article
- Article
- Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.Cell reports. Medicine · 2021Article
- Tracing the cellular basis of islet specification in mouse pancreas.Nature communications · 2020Article
- Spontaneous restoration of functional β-cell mass in obese SM/J mice.Physiological reports · 2020Article
- A Novel Pancreatic Imaging Window for Stabilized LongitudinalDiabetes & metabolism journal · 2020Article
- The Flaws and Future of Islet Volume Measurements.Cell transplantation · 2018Review
- Stereological analyses of the whole human pancreas.Scientific reports · 2016Article
- Dynamic development of the pancreas from birth to adulthood.Upsala journal of medical sciences · 2016Review
- Article
- Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction.Diabetes · 2015Article
- Diabetes Associated Metabolomic Perturbations in NOD Mice.Metabolomics : Official journal of the Metabolomic Society · 2015Article
- Development, growth and maintenance of β-cell mass: models are also part of the story.Molecular aspects of medicine · 2015Review
- Review
- Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis.The Journal of clinical investigation · 2014Article
- The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model.Physical biology · 2013Article
- Islet neogenesis: a possible pathway for beta-cell replenishment.The review of diabetic studies : RDS · 2012Review
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The islets of Langerhans, micro-organs for maintaining glucose homeostasis, range in size from small clusters of <10 cells to large islets consisting of several thousand endocrine cells. Islet size distributions among various species are similar and independent of body size, suggesting an intrinsic limit to islet size. Little is known about the mechanisms regulating islet size. We have carried out a comprehensive analysis of changes of islet size distribution in the intact mouse pancreas from birth to eight months, including mathematical modeling to quantify this dynamic biological process. Islet growth was size-dependent during development, with preferential expansion of smaller islets and fission of large interconnected islet-like structures occurring most actively at approximately three weeks of age at the time of weaning. The process of islet formation was complete by four weeks with little or no new islet formation thereafter, and all the β-cells had low proliferation potential in the adult, regardless of islet size. Similarly, in insulinoma-bearing mice, the early postnatal developmental process including fission followed the same time course with no new islet formation in adults. However, tumor progression led to uncontrolled islet growth with accelerated expansion of larger islets. Thus, islet formation and growth is a tightly regulated process involving preferential expansion of small islets and fission of large interconnected islet-like structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.