ArticleBiophysical journal2011
Redundant mechanisms for stable cell locomotion revealed by minimal models.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- Nonlinear Stability in a Free Boundary Model of Active Locomotion.Archive for rational mechanics and analysis · 2026Article
- Cell shape and orientation control galvanotactic accuracy.Soft matter · 2024Article
- The nonlinear motion of cells subject to external forces.Soft matter · 2022Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model.Frontiers in cell and developmental biology · 2021Article
- Actomyosin Contraction Induces In-Bulk Motility of Cells and Droplets.Biophysical journal · 2020Article
- CompuCell3D Simulations Reproduce Mesenchymal Cell Migration on Flat Substrates.Biophysical journal · 2020Article
- A minimal mechanosensing model predicts keratocyte evolution on flexible substrates.Journal of the Royal Society, Interface · 2020Article
- Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility.APL bioengineering · 2018Article
- A free-boundary model of a motile cell explains turning behavior.PLoS computational biology · 2017Article
- Free boundary problem for cell protrusion formations: theoretical and numerical aspects.Journal of mathematical biology · 2017Article
- Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.Physical review. E · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Spatial and temporal coordination of traction forces in one-dimensional cell migration.Cell adhesion & migration · 2016Article
- Computational analysis of amoeboid swimming at low Reynolds number.Journal of mathematical biology · 2016Article
- Article
- Crawling and Gliding: A Computational Model for Shape-Driven Cell Migration.PLoS computational biology · 2015Article
- On a poroviscoelastic model for cell crawling.Journal of mathematical biology · 2015Article
- Periodic migration in a physical model of cells on micropatterns.Physical review letters · 2013Article
- A kinetic model for RNA-interference of focal adhesions.BMC systems biology · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Crawling of eukaryotic cells on flat surfaces is underlain by the protrusion of the actin network, the contractile activity of myosin II motors, and graded adhesion to the substrate regulated by complex biochemical networks. Some crawling cells, such as fish keratocytes, maintain a roughly constant shape and velocity. Here we use moving-boundary simulations to explore four different minimal mechanisms for cell locomotion: 1), a biophysical model for myosin contraction-driven motility; 2), a G-actin transport-limited motility model; 3), a simple model for Rac/Rho-regulated motility; and 4), a model that assumes that microtubule-based transport of vesicles to the leading edge limits the rate of protrusion. We show that all of these models, alone or in combination, are sufficient to produce half-moon steady shapes and movements that are characteristic of keratocytes, suggesting that these mechanisms may serve redundant and complementary roles in driving cell motility. Moving-boundary simulations demonstrate local and global stability of the motile cell shapes and make testable predictions regarding the dependence of shape and speed on mechanical and biochemical parameters. The models shed light on the roles of membrane-mediated area conservation and the coupling of mechanical and biochemical mechanisms in stabilizing motile cells.
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