ArticleBehavioral and brain functions : BBF2011
Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice.
Article in Behavioral and brain functions : BBF, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Genetic risk for schizophrenia modulates WIN 55,212-2 reward: Evidence from a heterozygous transmembrane domain neuregulin 1 mutant mouse model.Psychopharmacology · 2026Article
- Cocaine sensitization and accumbens shell plasticity depend on biological sex and gonadal hormones in C57BL/6J mice.bioRxiv : the preprint server for biology · 2025Article
- Leveraging TRPV1 for intracellular delivery of membrane impermeant compounds in the brain.Scientific reports · 2025Article
- Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice.Psychopharmacology · 2023Article
- Role of Hormones in Substance Use Disorders.Neuroendocrinology · 2023Article
- Sex Differences in Cocaine Sensitization Vary by Mouse Strain.Neuroendocrinology · 2023Article
- High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice.Brain sciences · 2022Article
- Reinforcing effects of phenethylamine analogs found in dietary supplements.Psychopharmacology · 2022Article
- Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.Scientific reports · 2021Article
- Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.Brain research · 2021Article
- What Have We Learned (or Expect to) From Analysis of Murine Genetic Models Related to Substance Use Disorders?Frontiers in psychiatry · 2021Review
- The sigma receptor ligand N-phenylpropyl-N'-(4-methoxyphenethyl)3piperazine (YZ-067) enhances the cocaine conditioned-rewarding properties while inhibiting the development of sensitization of cocaine in mice.Psychopharmacology · 2020Article
- Article
- Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.Genes, brain, and behavior · 2019Article
- Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior.Cognitive, affective & behavioral neuroscience · 2019Review
- Food-induced reinforcement is abrogated by the genetic deletion of the MTBehavioural brain research · 2018Article
- Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants.Journal of psychopharmacology (Oxford, England) · 2018Article
- Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine.Neuroscience · 2017Article
- Sex differences in the acute locomotor response to methamphetamine in BALB/c mice.Behavioural brain research · 2017Article
- Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning.Nature neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors.
methodsC57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine.
resultsPlace preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice.
conclusionsGenetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.