ReviewScience progress2011
How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathway.
Review in Science progress, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Comparative Genomic Analysis and Data About the Metabolism of the GenusInternational journal of molecular sciences · 2026Article
- Novel utilization of the seaweed-based deoxy sugars rhamnose and fucose by engineered Corynebacterium glutamicum.Microbial cell factories · 2026Article
- Design and implementation of aerobic and ambient CONature communications · 2025Article
- Bringing carbon to life via one-carbon metabolism.Trends in biotechnology · 2025Review
- Metabolic pathways to sustainability: review of purple non-sulfur bacteria potential in agri-food waste valorization.Frontiers in bioengineering and biotechnology · 2025Review
- Collaborative metabolic curation of an emerging model marine bacterium, Alteromonas macleodii ATCC 27126.PloS one · 2025Article
- A novel engineered strain of Methylorubrum extorquens for methylotrophic production of glycolic acid.Microbial cell factories · 2024Article
- New-to-nature CONature communications · 2024Article
- From genome to evolution: investigating type II methylotrophs using a pangenomic analysis.mSystems · 2024Article
- Single carbon metabolism - A new paradigm for microbial bioprocesses?Synthetic and systems biotechnology · 2024Review
- Exploratory study on the metabolic similarity of denitrifying carbon sources.Environmental science and pollution research international · 2024Article
- Constructing efficient bacterial cell factories to enable one-carbon utilization based on quantitative biology: A review.Quantitative biology (Beijing, China) · 2024Review
- The Serine Shunt enables formate conversion to formaldehydeSustainable microbiology · 2024Article
- Metabolic engineering strategies for microbial utilization of methanol.Engineering microbiology · 2023Review
- Expanding Knowledge of Methylotrophic Capacity: Structure and Properties of the Rough-Type Lipopolysaccharide fromJACS Au · 2023Article
- Phylogeny and Metabolic Potential of the Methanotrophic Lineage MO3 in Beijerinckiaceae from the Paddy Soil through Metagenome-Assembled Genome Reconstruction.Microorganisms · 2022Article
- Comparative Genomics of Members of the GenusFrontiers in microbiology · 2022Article
- Aerobic Utilization of Methanol for Microbial Growth and Production.Advances in biochemical engineering/biotechnology · 2022Article
- Methane-dependent selenate reduction by a bacterial consortium.The ISME journal · 2021Article
- Levulinic Acid-Inducible and Tunable Gene Expression System forFrontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For bacterial growth on substrates with only one or two carbon atoms, special assimilation pathways are required. In 1957, the glyoxylate cycle of Kornberg and Krebs was described for bacterial growth on C2 compounds such as ethanol and acetate. However this pathway did not operate in some photosynthetic bacteria and in some methylotrophs when they were growing on C2 compounds, so an alternative pathway must exist. By 1973 Quayle's serine cycle had been described for methylotrophs growing on C1 compounds such as methanol, but the pathway was incomplete, the unknown part also functioning during growth on C2 compounds. After more than 35 further years of research, the ethylmalonyl-CoA (EMC) pathway for growth on C2 compounds, of photosynthetic bacteria has recently been elucidated. This pathway also operates in methylotrophs during growth on C2 compounds, and on C1 compounds by way of the serine cycle. This review is a celebration of half a century of research and of the fascinating result of that research.
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