Evidence map›Paper›PMID 21805826›Full record

ArticleInternational journal of data mining and bioinformatics2011

Activated germinal centre B cells undergo directed migration.

Mark J O'Connor, Anja E Hauser, Ann M Haberman, Steven H Kleinstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of data mining and bioinformatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mark J O'ConnorUniversity of Massachusetts Medical School, Worcester, MA 01655, USA. mark.oconnor@aya.yale.edu
Anja E Hauser
Ann M Haberman
Steven H Kleinstein
Yale University · USGerman Rheumatism Research Centre · DEUniversity of Massachusetts Chan Medical School · US

Funding

Yale Rheumatic Diseases Research Core CenterP30AR053495 · NIAMS · YALE UNIVERSITY · PI SHLOMCHIK, WARREN D · 2007 to 2017
$7.0M
In vivo imaging of T and B cell interactions in germinal center initiationR01AI080850 · NIAID · YALE UNIVERSITY · PI HABERMAN, ANN M · 2009 to 2012
$1.6M
NIAID NIH HHS R01 AI080850NIAID NIH HHS R01 AI080850-01A1NIAMS NIH HHS P30 AR053495
6 · The paper itself

Abstract

Affinity maturation, the fundamental basis for adaptive immunity, is accomplished through somatic hypermutation of B-cell receptors followed by expansion of rare mutants with higher affinity for the immunising antigen. This process occurs over a period of weeks in unique micro-anatomic sites known as germinal centres. Two-photon microscopy has recently made it possible to track individual cells moving within germinal centres in living animals. Here we apply statistical approaches to test the hypothesis that B-cell motion is random. Our results show that activated B cells move in a directed manner that sharply contrasts with the behaviour of naïve B cells.

Indexed as

Cell MovementAntigensB-LymphocytesCell CommunicationGerminal CenterReceptors, Antigen, B-CellAntigensReceptors, Antigen, B-Cell

Identifiers

PMID21805826
PMCPMC4343311
OpenAlexW2053441330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.