ArticleJournal of materials science. Materials in medicine2011
Preparation and characterization of electrospun PCL/PLGA membranes and chitosan/gelatin hydrogels for skin bioengineering applications.
Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Advances and Challenges in Tissue Engineering: Biomaterials, Cellular Strategies, and Clinical Applications.Journal of functional biomaterials · 2026Review
- Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior.Advanced healthcare materials · 2025Review
- Review
- Physical and Structural Properties of Chitosan-Squid Gelatin Hydrogels.Gels (Basel, Switzerland) · 2025Article
- Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study.Scientific reports · 2024Article
- Optimizing PCL/PLGA Scaffold Biocompatibility Using Gelatin from Bovine, Porcine, and Fish Origin.Gels (Basel, Switzerland) · 2023Article
- Article
- Preparation and Properties of (ScInternational journal of molecular sciences · 2023Article
- Bilayer Hydrogels for Wound Dressing and Tissue Engineering.Polymers · 2022Review
- Multifunctional Gelatin/Chitosan Electrospun Wound Dressing Dopped withPharmaceutics · 2021Article
- Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering.Materials (Basel, Switzerland) · 2021Article
- Fabrication and characterization of scaffolds containing different amounts of allantoin for skin tissue engineering.Scientific reports · 2021Article
- Recent Advances in Fiber-Hydrogel Composites for Wound Healing and Drug Delivery Systems.Antibiotics (Basel, Switzerland) · 2021Review
- Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review.Molecules (Basel, Switzerland) · 2020Review
- A two-layer skin construct consisting of a collagen hydrogel reinforced by a fibrin-coated polylactide nanofibrous membrane.International journal of nanomedicine · 2019Article
- Response of hPDLSCs on 3D printed PCL/PLGA composite scaffolds in vitro.Molecular medicine reports · 2018Article
- Relationships between mechanical properties and drug release from electrospun fibers of PCL and PLGA blends.Journal of the mechanical behavior of biomedical materials · 2017Article
- Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review.International journal of molecular sciences · 2016Review
- A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material.BioMed research international · 2015Article
- Design of chitosan and its water soluble derivatives-based drug carriers with polyelectrolyte complexes.Marine drugs · 2014Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, two distinct systems of biomaterials were fabricated and their potential use as a bilayer scaffold (BS) for skin bioengineering applications was assessed. The initial biomaterial was a polycaprolactone/poly(lacto-co-glycolic acid) (PCL/PLGA) membrane fabricated using the electrospinning method. The PCL/PLGA membrane M-12 (12% PCL/10% PLGA, 80:20) displayed strong mechanical properties (stress/strain values of 3.01 ± 0.23 MPa/225.39 ± 7.63%) and good biocompatibility as demonstrated by adhesion of keratinocyte cells on the surface and ability to support cell proliferation. The second biomaterial was a hydrogel composed of 2% chitosan and 15% gelatin (50:50) crosslinked with 5% glutaraldehyde. The CG-3.5 hydrogel (with 3.5% glutaraldehyde (v/v)) displayed a high porosity, ≥97%, good compressive strength (2.23 ± 0.25 MPa), ability to swell more than 500% of its dry weight and was able to support fibroblast cell proliferation. A BS was fabricated by underlaying the membrane and hydrogel casting method to combine these two materials. The physical properties and biocompatibility were preliminarily investigated and the properties of the two biomaterials were shown to be complementary when combined. The upper layer membrane provided mechanical support in the scaffold and reduced the degradation rate of the hydrogel layer. Cell viability was similar to that in the hydrogel layer which suggests that addition of the membrane layer did not affect the biocompatibility.
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Registered trials
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