ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2012
The impact of diabetes on the pathogenesis of sepsis.
Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04015752 (Sepsis in Intensive Care Unit), which is not on this map. Cited by 96 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sepsis in Intensive Care Unit :Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital
Who cites it
96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 220 citations in OpenAlex.
- The double burden of diabetes and global infection in low and middle-income countries.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Pooled it
- Meta-analysis of peritoneal lavage in appendicectomy.BJS open · 2019Pooled it
- Effect of hemoadsorption during cardiopulmonary bypass surgery - a blinded, randomized, controlled pilot study using a novel adsorbent.Critical care (London, England) · 2016Trial
- Rates of serious intracellular infections in autoimmune disease patients receiving initial glucocorticoid therapy.PloS one · 2013Trial
- Article
- Stress Hyperglycemia Ratio and the Risk of Sepsis in Patients With Heart Failure: Retrospective Cohort Study From Medical Information Mart for Intensive Care-IV.JMIR medical informatics · 2026Article
- Prognostic Nutritional Index (PNI) in Patients With Diabetes and Sepsis: A Cross-Sectional Study.Cureus · 2026Article
- Prognostic value of the creatinine-to-albumin ratio for 28-day mortality in patients with sepsis and diabetes: integrating renal and nutritional status in the ICU.Frontiers in nutrition · 2026Article
- Disseminated melioidosis complicated by symmetrical peripheral gangrene and multi-organ failure: a case report.Frontiers in immunology · 2026Article
- Premature Mortality from Type 2 Diabetes Mellitus Attributable to Household Air Pollution from Solid Fuels in Eastern Sub-Saharan Africa, 1990 to 2023.Environmental health insights · 2026Article
- Long-term trends in diabetes mellitus and sepsis-related mortality in the united states: a population-based retrospective analysis (1999-2024).Journal of diabetes and metabolic disorders · 2025Article
- Immune dysregulation in type 2 diabetes mellitus: Implications for tuberculosis, COVID-19, and HIV/AIDS.Infectious medicine · 2025Review
- Genetic links between psychological distress, sleep disorders, and sepsis risk: a Mendelian randomization study.International journal of clinical pharmacy · 2025Article
- Association of cancers with the occurrence and 28-day mortality of sepsis: a mendelian randomization and mediator analysis.Scientific reports · 2025Article
- Edges are all you need: Potential of medical time series analysis on complete blood count data with graph neural networks.PloS one · 2025Article
- The Effect of Ozone on Kidney and Liver Tissues in the Treatment of Sepsis Caused by Cecal Perforation in Diabetic Mice.Drug design, development and therapy · 2025Article
- XueBiJing injection reduced mortality in sepsis patients with diabetes.Frontiers in pharmacology · 2025Article
- Assessment of adverse pregnancy outcomes associated with Helicobacter pylori infection.Scientific reports · 2024Article
- Article
- Prevalence and outcomes of chronic comorbid conditions in patients with sepsis in Korea: a nationwide cohort study from 2011 to 2016.BMC infectious diseases · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.