ReviewHistochemistry and cell biology2011
MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications.
Review in Histochemistry and cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 119 citations in OpenAlex.
- Recent progress in nanomaterial-enhanced SALDI-MSI for spatial metabolomics.Analytical and bioanalytical chemistry · 2026Review
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- Unified mass imaging maps the lipidome of vertebrate development.Nature methods · 2025Article
- Direct sub-atmospheric pressure ionization mass spectrometry: Evaporation/sublimation-driven ionization is amazing, fundamentally, and practically.Journal of mass spectrometry : JMS · 2024Review
- How to sample a seizure plant: the role of the visualization spatial distribution analysis ofForensic sciences research · 2023Article
- Histochemistry and Cell Biology-a glance into the past and a look ahead.Histochemistry and cell biology · 2023Review
- Evaluation and comparison of unsupervised methods for the extraction of spatial patterns from mass spectrometry imaging data (MSI).Scientific reports · 2022Article
- Sample preparation strategy for the detection of steroid-like compounds using MALDI mass spectrometry imaging: pulmonary distribution of budesonide as a case study.Analytical and bioanalytical chemistry · 2021Article
- Light sheet fluorescence microscopy guided MALDI-imaging mass spectrometry of cleared tissue samples.Scientific reports · 2020Article
- Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer.Cancer reports (Hoboken, N.J.) · 2019Review
- Chemometric Strategies for Sensitive Annotation and Validation of Anatomical Regions of Interest in Complex Imaging Mass Spectrometry Data.Journal of the American Society for Mass Spectrometry · 2019Article
- Improvement of Sensitivity and Reproducibility for Imaging of Endogenous Metabolites by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- A Novel Mass Spectrometry Platform for Multiplexed N-Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N-Glycan Imaging.Analytical chemistry · 2019Article
- The Influence of MS Imaging Parameters on UV-MALDI Desorption and Ion Yield.Journal of the American Society for Mass Spectrometry · 2019Article
- A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry.Scientific reports · 2019Article
- Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity.Analytical chemistry · 2018Article
- Matrix Optical Absorption in UV-MALDI MS.Journal of the American Society for Mass Spectrometry · 2018Article
- High-Resolution Tissue Mass Spectrometry Imaging Reveals a Refined Functional Anatomy of the Human Adult Adrenal Gland.Endocrinology · 2018Article
- Article
- Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a method that allows the investigation of the molecular content of tissues within its morphological context. Since it is able to measure the distribution of hundreds of analytes at once, while being label free, this method has great potential which has been increasingly recognized in the field of tissue-based research. In the last few years, MALDI-IMS has been successfully used for the molecular assessment of tissue samples mainly in biomedical research and also in other scientific fields. The present article will give an update on the application of MALDI-IMS in clinical and preclinical research. It will also give an overview of the multitude of technical advancements of this method in recent years. This includes developments in instrumentation, sample preparation, computational data analysis and protein identification. It will also highlight a number of emerging fields for application of MALDI-IMS like drug imaging where MALDI-IMS is used for studying the spatial distribution of drugs in tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.