Evidence map›Paper›PMID 21804977›Full record

ReviewPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2012

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.

Gerd P Pfeifer, Ahmad Besaratinia

Open access · greenAbstract readReview
In one paragraph

Review in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 2 pooled it
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 2 syntheses or guidelines pooled it, 461 citations in OpenAlex.

  1. Pooled it
  2. Managing infectious aerosols to counter engineered pandemics: Current recommendations and future research.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Guideline
  3. Trial
  4. Trial
  5. Cutaneous Aging in Skin of Color: A Narrative Review.American journal of clinical dermatology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Tailored TiOACS applied engineering materials · 2026
    Article
  12. Article
  13. Design of 222 nm UV-C experimental device and experiment on the effect of radiation on the quality of post-harvested fresh tomatoes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  14. Review
  15. Article
  16. Dermatological effects of acute and long-term UV-C exposure: an in vivo study using a portable mercury lamp.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  17. Counteracting Skin Aging In Vitro by Phytochemicals.Journal of cellular and molecular medicine · 2025
    Article
  18. Article
  19. Review
  20. Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gerd P PfeiferDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. gpfeifer@coh.org
Ahmad Besaratinia
Beckman Research InstituteCity Of Hope National Medical Center · US

Funding

UV damage, repair, and mutagenesisR37ES006070 · NIEHS · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI PFEIFER, GERD P · 2004 to 2013
$3.7M
UV DAMAGE, REPAIR AND MUTAGENESISR01ES006070 · NIEHS · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI PFEIFER, GERD P · 1992 to 2003
$1.1M
NIEHS NIH HHS ES 06070NIEHS NIH HHS R01 ES006070NIEHS NIH HHS R37 ES006070
6 · The paper itself

Abstract

Ultraviolet (UV) irradiation from the sun has been epidemiologically and mechanistically linked to skin cancer, a spectrum of diseases of rising incidence in many human populations. Both non-melanoma and melanoma skin cancers are associated with sunlight exposure. In this review, we discuss the UV wavelength-dependent formation of the major UV-induced DNA damage products, their repair and mutagenicity and their potential involvement in sunlight-associated skin cancers. We emphasize the major role played by the cyclobutane pyrimidine dimers (CPDs) in skin cancer mutations relative to that of (6-4) photoproducts and oxidative DNA damage. Collectively, the data implicate the CPD as the DNA lesion most strongly involved in human cancers induced by sunlight.

Indexed as

DNA DamageUltraviolet RaysHumansMelanomaMutationNeoplasms, Radiation-InducedPyrimidine DimersSkin NeoplasmsPyrimidine Dimers

Identifiers

PMID21804977
PMCPMC3289542
OpenAlexW2019399071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.