ArticleBasal ganglia2011
GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation.
Article in Basal ganglia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- GPR88 localization to primary cilia in neurons is cell-type specific.Life science alliance · 2026Article
- Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling.Neurochemical research · 2025Article
- Orphan GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches.Current issues in molecular biology · 2024Review
- Graph attention automatic encoder based on contrastive learning for domain recognition of spatial transcriptomics.Communications biology · 2024Article
- Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder.British journal of pharmacology · 2024Review
- Design, Synthesis, and Structure-Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl)acetamides Based on the Reversed Amide Scaffold.ACS chemical neuroscience · 2024Article
- Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation.Journal of medicinal chemistry · 2023Article
- Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor.Bioorganic & medicinal chemistry letters · 2023Article
- Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Spatial tissue profiling by imaging-free molecular tomography.Nature biotechnology · 2021Article
- G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.Journal of psychiatry & neuroscience : JPN · 2021Article
- Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists.Journal of medicinal chemistry · 2020Article
- Review
- The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs.eLife · 2020Article
- Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target.ACS chemical neuroscience · 2019Review
- Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping.Genes, brain, and behavior · 2018Article
- Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.Journal of medicinal chemistry · 2018Article
- Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.Brain structure & function · 2018Article
- Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.Brain connectivity · 2017Article
- GPR88 is a critical regulator of feeding and body composition in mice.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
GPR88 is a putative G-protein-coupled receptor that is highly and almost exclusively expressed in the striatum. Its function remains unknown. We investigated GPR88 cellular localization and expression levels across development in different functional domains of the striatum in juvenile (P25), adolescent (P40), and adult (P70) rats, by in situ hybridization histochemistry. At all ages, GPR88 mRNA expression was most robust in the sensorimotor (lateral) striatum and was detected in virtually every neuron. Expression was highest in juveniles and decreased thereafter with regionally distinct trajectories. Thus, in the dorsal striatum, there was a progressive decrease from juveniles to adolescents to adults. In contrast, in the nucleus accumbens, the only (modest) decrease occurred between juveniles and adolescents. These findings indicate that GPR88 is expressed in all striatal neurons, but is differentially regulated across development in different striatal regions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.