ArticleEvidence-based complementary and alternative medicine : eCAM2011
Assessing the effects of acupuncture by comparing needling the hegu acupoint and needling nearby nonacupoints by spectral analysis of microcirculatory laser Doppler signals.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Trial
- Exploring the Relationship between Blood Flux Signals and HRV following Different Thermal Stimulations using Complexity Analysis.Scientific reports · 2018Trial
- Acupuncture at KI3 in healthy volunteers induces specific cortical functional activity: an fMRI study.BMC complementary and alternative medicine · 2015Trial
- Local changes in microcirculation and the analgesic effects of acupuncture: a laser Doppler perfusion imaging study.Journal of alternative and complementary medicine (New York, N.Y.) · 2015Trial
- Auricular acupuncture for chemically dependent pregnant women: a randomized controlled trial of the NADA protocol.Substance abuse treatment, prevention, and policy · 2012Trial
- Comparison of two acupuncture stimulation techniques at Hegu (LI4) on muscle and fascia stiffness, blood flow, and quality of life in healthy female volunteers.American journal of translational research · 2026Article
- Pressure stimulus study on acupuncture points with multi-channel multimode-fiber diffuse speckle contrast analysis (MMF-DSCA).Biomedical optics express · 2023Article
- The Moxibustion-Induced Thermal Transport Effect Between the Heart and Lung Meridians With Infrared Thermography.Frontiers in cardiovascular medicine · 2022Article
- Pilot Study of Blood Perfusion Changes at PC4 and Its Surrounding Points Induced by Acupuncture and Moxibustion.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Multipoint transcutaneous electrical stimulation reduces median effective plasma concentration of propofol: A randomised clinical trial.Indian journal of anaesthesia · 2020Article
- The microcirculatory characteristics of the heart and lung meridians: Study protocol clinical trial (SPIRIT Compliant).Medicine · 2020Article
- Use of Acupuncture in an Infant with Restlessness and Agitation.Medicines (Basel, Switzerland) · 2018Article
- Changes in Nitric Oxide Releases of the Contralateral Acupoint during and after Laser Acupuncture at Bilateral Same-Name Acupoints in Human.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Response of Blood Perfusion at ST 36 Acupoint after Drinking Cold Glucose or Saline Injection.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Changes of Blood Flux at BL21 and Points along BL Meridian Resulted from Acupuncture or Moxibustion: Case Cross Design Study.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Changes of locoregional skin temperature in neonates undergoing laser needle acupuncture at the acupuncture point large intestine 4.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Acupoint Activation: Response in Microcirculation and the Role of Mast Cells.Medicines (Basel, Switzerland) · 2014Review
- The Effect of Acupuncture to SP6 on Skin Temperature Changes of SP6 and SP10: An Observation of "Deqi".Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Decreased peripheral and central responses to acupuncture stimulation following modification of body ownership.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to assess the effects of acupuncture by analyzing the frequency content of skin blood-flow signals simultaneously recorded at the Hegu acupoint and two nearby nonacupoints following acupuncture stimulation (AS). Laser Doppler flowmetry (LDF) signals were measured in male healthy volunteers in two groups of experiments: needling the Hegu acupoint (n = 13) and needling a nearby nonacupoint (control experiment; n = 10). Each experiment involved recording a 20 min baseline-data sequence and two sets of effects data recorded 0-20 and 50-70 min after stopping AS. Wavelet transform with Morlet mother wavelet was applied to the measured LDF signals. Needling the Hegu acupoint significantly increased the blood flow, significantly decreased the relative energy contribution at 0.02-0.06 Hz and significantly increased the relative energy contribution at 0.4-1.6 Hz at Hegu, but induced no significant changes at the nonacupoints. Also, needling a nearby nonacupoint had no effect in any band at any site. This is the first time that spectral analysis has been used to investigate the microcirculatory blood-flow responses induced by AS, and has revealed possible differences in sympathetic nerve activities between needling the Hegu acupoint and its nearby nonacupoint. One possible weakness of the present design is that different De-Qi feelings following AS could lead to nonblind experimental setup, which may bias the comparison between needling Hegu and its nearby nonacupoint. Our results suggest that the described noninvasive method can be used to evaluate sympathetic control of peripheral vascular activity, which might be useful for studying the therapeutic effects of AS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.