ArticleNew journal of physics2011
Mechanisms of Cell Propulsion by Active Stresses.
Article in New journal of physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Frictiotaxis underlies focal adhesion-independent durotaxis.Nature communications · 2025Article
- Elastic interactions compete with persistent cell motility to drive durotaxis.Biophysical journal · 2024Article
- Critical role of lipid membranes in polarization and migration of cells: a biophysical view.Biophysical reviews · 2021Review
- Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Tuning Cell Motility via Cell Tension with a Mechanochemical Cell Migration Model.Biophysical journal · 2020Article
- Simple Physical Model Unravels Influences of Chemokine on Shape Deformation and Migration of Human Hematopoietic Stem Cells.Scientific reports · 2018Article
- A free-boundary model of a motile cell explains turning behavior.PLoS computational biology · 2017Article
- A simple force-motion relation for migrating cells revealed by multipole analysis of traction stress.Biophysical journal · 2014Article
- Periodic migration in a physical model of cells on micropatterns.Physical review letters · 2013Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Effects of adhesion dynamics and substrate compliance on the shape and motility of crawling cells.PloS one · 2013Article
- Coupling actin flow, adhesion, and morphology in a computational cell motility model.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The mechanisms by which cytoskeletal flows and cell-substrate interactions interact to generate cell motion are explored using a simplified model of the cytoskeleton as a viscous gel containing active stresses. This model yields explicit general results relating cell speed and traction forces to the distributions of active stress and cell-substrate friction. It is found that 1) the cell velocity is given by a function that quantifies the asymmetry of the active-stress distribution, 2) gradients in cell-substrate friction can induce motion even when the active stresses are symmetrically distributed, 3) the traction-force dipole is enhanced by protrusive stresses near the cell edges or contractile stresses near the center of the cell, and 4) the cell velocity depends biphasically on the cell-substrate adhesion strength if active stress is enhanced by adhesion. Specific experimental tests of the calculated dependences are proposed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.