ArticleMedical science monitor : international medical journal of experimental and clinical research2011
The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Different Effect of Dienogest on Endometrium Mesenchymal Stem Cells Derived from Healthy and Endometriosis TissuesBalkan medical journal · 2024Article
- NOTCH1- and CD117-Positive Stem Cells in Human Endometriosis and Adenomyosis Lesions.Diagnostics (Basel, Switzerland) · 2024Article
- Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps.International journal of molecular sciences · 2024Article
- Comparison of the regenerative effects of bone marrow/adipose-derived stem cells in the Asherman model following local or systemic administration.Journal of assisted reproduction and genetics · 2020Article
- Telomerase and Telomeres in Endometrial Cancer.Frontiers in oncology · 2019Review
- Implications of telomeres and telomerase in endometrial pathology.Human reproduction update · 2017Review
- The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious.International journal of clinical and experimental pathology · 2015Article
- Increased importin 13 activity is associated with the pathogenesis of pterygium.Molecular vision · 2013Article
- Increased expression of importin13 in endometriosis and endometrial carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- E2F1: a potential negative regulator of hTERT transcription in normal cells upon activation of oncogenic c-Myc.Medical science monitor : international medical journal of experimental and clinical research · 2012Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the expression levels of importin13 (IPO13), c-kit, CD146, telomerase, caspase-3, bcl-2 and bax in endometrial polyps (EPs). MATERIAL/
methodsWe detected the mRNA expression levels of IPO13, c-kit, bcl-2 and bax in endometrial polyps (EPs) using real-time PCR. We detected the protein expression levels of IPO13, telomerase, CD146, caspase-3, bcl-2 and bax in EPs using S-P (Streptavidin-Peroxidase) immunohistochemistry. Western blotting was performed to determine the levels of importin13 and bcl-2 proteins in EPs.
resultsThe expression levels of IPO13, c-kit, telomerase, caspase3, and bax were lower in the EP tissue compared to normal endometrial tissue during the proliferation and secretion phases of the menstrual cycle (p<0.05). The expression of CD146 was decreased in the EP tissue compared to the normal endometrial tissue during the proliferation phase of the menstrual cycle (p<0.05). The expression of bcl-2 was increased in the EP tissue compared to the normal endometrial tissue during the proliferation and secretion phases of the menstrual cycle (p<0.05).
conclusionsThe expression levels of IPO13, c-kit, telomerase, caspase3, and bax were decreased; however, the expression of bcl-2 was increased in the EP tissue compared to the normal endometrial tissue. These findings suggest that the development of EPs is associated with the deregulated activities of the endometrial stem/progenitor cells and the decreased apoptosis of endometrial cells, with the latter being the major factor involved in the development of EPs.
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