ArticleJournal of the American Society of Nephrology : JASN2011
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Comparative analysis ofbioRxiv : the preprint server for biology · 2025Article
- The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Reversion induced LIM domain protein (RIL) is a Daam1-interacting protein and regulator of the actin cytoskeleton during non-canonical Wnt signaling.Developmental biology · 2024Article
- Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation.Scientific reports · 2023Article
- Formins in Human Disease.Cells · 2021Review
- Article
- Planar cell polarity pathway in kidney development, function and disease.Nature reviews. Nephrology · 2021Review
- The Biological Significance and Implications of Planar Cell Polarity for Nephrology.Frontiers in physiology · 2021Review
- Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.American journal of human genetics · 2020Article
- The Drosophila actin nucleator DAAM is essential for left-right asymmetry.PLoS genetics · 2020Article
- Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled.The Journal of cell biology · 2019Article
- Review
- Article
- Dynamin Binding Protein Is Required forFrontiers in physiology · 2019Article
- Regulation of neural crest development by the formin family protein Daam1.Genesis (New York, N.Y. : 2000) · 2018Article
- Article
- Wnt Signaling in Kidney Development and Disease.Progress in molecular biology and translational science · 2018Review
- Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels.Scientific reports · 2017Article
- Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.Cell cycle (Georgetown, Tex.) · 2017Article
- Xenopus: leaping forward in kidney organogenesis.Pediatric nephrology (Berlin, Germany) · 2017Review
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9 authors at 5 institutions in 2 countries.
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Abstract
Canonical β-catenin-mediated Wnt signaling is essential for the induction of nephron development. Noncanonical Wnt/planar cell polarity (PCP) pathways contribute to processes such as cell polarization and cytoskeletal modulation in several tissues. Although PCP components likely establish the plane of polarization in kidney tubulogenesis, whether PCP effectors directly modulate the actin cytoskeleton in tubulogenesis is unknown. Here, we investigated the roles of Wnt PCP components in cytoskeletal assembly during kidney tubule morphogenesis in Xenopus laevis and zebrafish. We found that during tubulogenesis, the developing pronephric anlagen expresses Daam1 and its interacting Rho-GEF (WGEF), which compose one PCP/noncanonical Wnt pathway branch. Knockdown of Daam1 resulted in reduced expression of late pronephric epithelial markers with no apparent effect upon early markers of patterning and determination. Inhibiting various points in the Daam1 signaling pathway significantly reduced pronephric tubulogenesis. These data indicate that pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.