ArticleJournal of bacteriology2011
Genomes and characterization of phages Bcep22 and BcepIL02, founders of a novel phage type in Burkholderia cenocepacia.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 48 citations in OpenAlex.
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- Burkholderia contaminans Bacteriophage CSP3 Requires O-Antigen Polysaccharides for Infection.Microbiology spectrum · 2023Article
- Characterization and complete genome sequence analysis of the novel phage RPZH3 infecting Ralstonia solanacearum.Archives of virology · 2023Article
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- Intravirion DNA Can Access the Space Occupied by the Bacteriophage P22 Ejection Proteins.Viruses · 2021Article
- Advances in Phage Therapy: Targeting theViruses · 2021Review
- High genomic diversity of novel phages infecting the plant pathogen Ralstonia solanacearum, isolated in Mauritius and Reunion islands.Scientific reports · 2021Article
- Novel Virus on Filamentous Arthronema africanum Cyanobacterium.Microbial ecology · 2021Article
- Differential Bacteriophage Efficacy in ControllingFrontiers in microbiology · 2021Article
- Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of the CsrA Family in the GenusFrontiers in molecular biosciences · 2020Article
- Complete Genome Sequence ofMicrobiology resource announcements · 2019Article
- Complete Genome Sequence of Serratia marcescens Podophage Parlo.Microbiology resource announcements · 2019Article
- Isolation and Characterization T4- and T7-Like Phages that Infect the Bacterial Plant PathogenViruses · 2019Article
- Cyanophage A-1(L) Adsorbs to Lipopolysaccharides ofJournal of bacteriology · 2019Article
- Molecular and Biological Characterization of Ralstonia Phage RsoM1USA, a New Species ofFrontiers in microbiology · 2019Article
- Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity.Journal of virology · 2018Article
- Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Within the Burkholderia cepacia complex, B. cenocepacia is the most common species associated with aggressive infections in the lungs of cystic fibrosis patients, causing disease that is often refractive to treatment by antibiotics. Phage therapy may be a potential alternative form of treatment for these infections. Here we describe the genome of the previously described therapeutic B. cenocepacia podophage BcepIL02 and its close relative, Bcep22. Phage Bcep22 was found to contain a circularly permuted genome of 63,882 bp containing 77 genes; BcepIL02 was found to be 62,714 bp and contains 76 predicted genes. Major virion-associated proteins were identified by proteomic analysis. We propose that these phages comprise the founding members of a novel podophage lineage, the Bcep22-like phages. Among the interesting features of these phages are a series of tandemly repeated putative tail fiber genes that are similar to each other and also to one or more such genes in the other phages. Both phages also contain an extremely large (ca. 4,600-amino-acid), virion-associated, multidomain protein that accounts for over 20% of the phages' coding capacity, is widely distributed among other bacterial and phage genomes, and may be involved in facilitating DNA entry in both phage and other mobile DNA elements. The phages, which were previously presumed to be virulent, show evidence of a temperate lifestyle but are apparently unable to form stable lysogens in their hosts. This ambiguity complicates determination of a phage lifestyle, a key consideration in the selection of therapeutic phages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.