ArticleAmerican journal of physiology. Heart and circulatory physiology2011
ATP hydrolysis pathways and their contributions to pial arteriolar dilation in rats.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- To err, KAmerican journal of physiology. Heart and circulatory physiology · 2023Article
- Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function.International journal of molecular sciences · 2022Review
- Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer's Disease.Frontiers in physiology · 2021Article
- Nucleotide P2YPurinergic signalling · 2020Article
- Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?Neurochemistry international · 2019Review
- Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor.Brain research · 2017Article
- Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle.Frontiers in cellular neuroscience · 2017Article
- A commonly used ecto-ATPase inhibitor, ARL-67156, blocks degradation of ADP more than the degradation of ATP in murine colon.Neurogastroenterology and motility · 2016Article
- Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone.Neuroscience · 2016Review
- Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca(2+) signaling.Frontiers in cellular neuroscience · 2015Review
- Neurovascular signaling in the brain and the pathological consequences of hypertension.American journal of physiology. Heart and circulatory physiology · 2014Review
- Astrocyte regulation of cerebral vascular tone.American journal of physiology. Heart and circulatory physiology · 2013Review
- Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BK(Ca) and Kir channels.American journal of physiology. Heart and circulatory physiology · 2012Article
- Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.American journal of physiology. Heart and circulatory physiology · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
ATP is thought to be released to the extracellular compartment by neurons and astrocytes during neural activation. We examined whether ATP exerts its effect of promoting pial arteriolar dilation (PAD) directly or upon conversion (via ecto-nucleotidase action) to AMP and adenosine. Blockade of extracellular direct ATP to AMP conversion, with ARL-67156, significantly reduced sciatic nerve stimulation-evoked PADs by 68%. We then monitored PADs during suffusions of ATP, ADP, AMP, and adenosine in the presence and absence of the following: 1) the ecto-5'-nucleotidase inhibitor α,β-methylene adenosine 5'-diphosphate (AOPCP), 2) the A(2) receptor blocker ZM 241385, 3) the ADP P2Y(1) receptor antagonist MRS 2179, and 4) ARL-67156. Vasodilations induced by 1 and 10 μM, but not 100 μM, ATP were markedly attenuated by ZM 241385, AOPCP, and ARL-67156. Substantial loss of reactivity to 100 μM ATP required coapplications of ZM 241385 and MRS 2179. Dilations induced by ADP were blocked by MRS 2179 but were not affected by either ZM 241385 or AOPCP. AMP-elicited dilation was partially inhibited by AOPCP and completely abolished by ZM 241385. Collectively, these and previous results indicate that extracellular ATP-derived adenosine and AMP, via A(2) receptors, play key roles in neural activation-evoked PAD. However, at high extracellular ATP levels, some conversion to ADP may occur and contribute to PAD through P2Y(1) activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.