ArticleApplied and environmental microbiology2011
Predominant effect of host genetics on levels of Lactobacillus johnsonii bacteria in the mouse gut.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- The host genotype actively shapes its microbiome across generations in laboratory mice.Microbiome · 2024Article
- What happens to Bifidobacterium adolescentis and Bifidobacterium longum ssp. longum in an experimental environment with eukaryotic cells?BMC microbiology · 2024Article
- Hybridization alters red deer gut microbiome and metabolites.Frontiers in microbiology · 2024Article
- Effects of melatonin on rumen microorganisms and methane production in dairy cow: results from in vitro and in vivo studies.Microbiome · 2023Article
- Precise strategies for selecting probiotic bacteria in treatment of intestinal bacterial dysfunctional diseases.Frontiers in immunology · 2022Review
- Review
- Impact of host genetics on gut microbiome: Take-home lessons from human and mouse studies.Animal models and experimental medicine · 2020Review
- Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics.Experimental & molecular medicine · 2020Review
- The Effects of In Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome, Host Immunity, and Susceptibility to a Bacterial Infection in Earthworms.Nanomaterials (Basel, Switzerland) · 2020Article
- Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine.Microbiome · 2020Article
- Murine Genetic Background Has a Stronger Impact on the Composition of the Gut Microbiota than Maternal Inoculation or Exposure to Unlike Exogenous Microbiota.Applied and environmental microbiology · 2019Article
- Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice.Frontiers in cellular and infection microbiology · 2018Article
- Host-genotype dependent gut microbiota drives zooplankton tolerance to toxic cyanobacteria.Nature communications · 2017Article
- Understanding host-microbial interactions in rumen: searching the best opportunity for microbiota manipulation.Journal of animal science and biotechnology · 2017Review
- Draft Genome Sequence of Lactobacillus johnsonii Strain 16, Isolated from Mice.Genome announcements · 2015Article
- The composition of the gut microbiota throughout life, with an emphasis on early life.Microbial ecology in health and disease · 2015Article
- Variation in Taxonomic Composition of the Fecal Microbiota in an Inbred Mouse Strain across Individuals and Time.PloS one · 2015Article
- Viable intestinal passage of a canine jejunal commensal strain Lactobacillus acidophilus LAB20 in dogs.Current microbiology · 2014Article
- High through put 16S rRNA gene-based pyrosequencing analysis of the fecal microbiota of high FCR and low FCR broiler growers.Molecular biology reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota is strongly associated with the well-being of the host. Its composition is affected by environmental factors, such as food and maternal inoculation, while the relative impact of the host's genetics have been recently uncovered. Here, we studied the effect of the host genetic background on the composition of intestinal bacteria in a murine model, focusing on lactic acid bacteria (LAB) as an important group that includes many probiotic strains. Based on 16S rRNA gene genotyping, variation was observed in fecal LAB populations of BALB/c and C57BL/6J mouse lines. Lactobacillus johnsonii, a potentially probiotic bacterium, appeared at significantly higher levels in C57BL/6J versus BALB/c mouse feces. In the BALB/c gut, the L. johnsonii level decreased rapidly after oral administration, suggesting that some selective force does not allow its persistence at higher levels. The genetic inheritance of L. johnsonii levels was further tested in reciprocal crosses between the two mouse lines. The resultant F1 offspring presented similar L. johnsonii levels, confirming that mouse genetics plays a major role in determining these levels compared to the smaller maternal effect. Our findings suggest that mouse genetics has a major effect on the composition of the LAB population in general and on the persistence of L. johnsonii in the gut in particular. Concentrating on a narrow spectrum of culturable LAB enables the isolation and characterization of such potentially probiotic bacterial strains, which might be specifically oriented to the genetic background of the host as part of a personalized-medicine approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.