ArticleEukaryotic cell2011
CCR4-associated factor 1 coordinates the expression of Plasmodium falciparum egress and invasion proteins.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum.Nature communications · 2026Article
- Integrative genomics ofbioRxiv : the preprint server for biology · 2026Article
- Article
- Single-cell RNA profiling ofFrontiers in cellular and infection microbiology · 2022Article
- The Plasmodium NOT1-G paralogue is an essential regulator of sexual stage maturation and parasite transmission.PLoS biology · 2021Article
- Genome-Wide and Comprehensive Analysis of the Multiple Stress-Related CAF1 (CCR4-Associated Factor 1) Family and Its Expression in Poplar.Plants (Basel, Switzerland) · 2021Article
- An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum.Scientific reports · 2021Article
- The chromatin bound proteome of the human malaria parasite.Microbial genomics · 2020Article
- Unraveling the 3D genome of human malaria parasites.Seminars in cell & developmental biology · 2019Review
- Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex.PLoS pathogens · 2019Article
- Uncovering the essential genes of the human malaria parasiteScience (New York, N.Y.) · 2018Article
- The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.Trends in parasitology · 2017Review
- Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way.Wiley interdisciplinary reviews. RNA · 2016Review
- Signaling transcript profile of the asexual intraerythrocytic development cycle ofGenes & cancer · 2016Article
- The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum.Genome biology · 2016Article
- A Stem Cell Strategy Identifies Glycophorin C as a Major Erythrocyte Receptor for the Rodent Malaria Parasite Plasmodium berghei.PloS one · 2016Article
- A bioinformatic survey of RNA-binding proteins in Plasmodium.BMC genomics · 2015Article
- PfAlba1: master regulator of translation in the malaria parasite.Genome biology · 2015Article
- The PfAlba1 RNA-binding protein is an important regulator of translational timing in Plasmodium falciparum blood stages.Genome biology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Coordinated regulation of gene expression is a hallmark of the Plasmodium falciparum asexual blood-stage development cycle. We report that carbon catabolite repressor protein 4 (CCR4)-associated factor 1 (CAF1) is critical in regulating more than 1,000 genes during malaria parasites' intraerythrocytic stages, especially egress and invasion proteins. CAF1 knockout results in mistimed expression, aberrant accumulation and localization of proteins involved in parasite egress, and invasion of new host cells, leading to premature release of predominantly half-finished merozoites, drastically reducing the intraerythrocytic growth rate of the parasite. This study demonstrates that CAF1 of the CCR4-Not complex is a significant gene regulatory mechanism needed for Plasmodium development within the human host.
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