ArticleGenome biology and evolution2011
Selection for translation efficiency on synonymous polymorphisms in recent human evolution.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
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- A novel age-informed approach for genetic association analysis in Alzheimer's disease.Alzheimer's research & therapy · 2021Article
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- Contrasting Patterns of Rapid Molecular Evolution within the p53 Network across Mammal and Sauropsid Lineages.Genome biology and evolution · 2019Article
- Identification of a synonymous variant in TRIM59 gene for gastric cancer risk in a Chinese population.Oncotarget · 2017Article
- Explosive genetic evidence for explosive human population growth.Current opinion in genetics & development · 2016Review
- Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer.Scientific reports · 2016Article
- Association Study Between SLC15A4 Polymorphisms and Haplotypes and Systemic Lupus Erythematosus in a Han Chinese Population.Genetic testing and molecular biomarkers · 2016Article
- Association analysis ofOncoTargets and therapy · 2016Article
- The Code of Silence: Widespread Associations Between Synonymous Codon Biases and Gene Function.Journal of molecular evolution · 2016Review
- The functional relevance of somatic synonymous mutations in melanoma and other cancers.Pigment cell & melanoma research · 2015Review
- Multiple roles of the coding sequence 5' end in gene expression regulation.Nucleic acids research · 2015Review
- Synonymous Polymorphisms in HOXB13 as a Protective Factor for Prostate Cancer.Journal of Cancer · 2015Article
- Effective population size does not predict codon usage bias in mammals.Ecology and evolution · 2014Article
- Impairment of translation in neurons as a putative causative factor for autism.Biology direct · 2014Article
- No impact of SLCO1B1 521T>C, 388A>G and 411G>A polymorphisms on response to statin therapy in the Greek population.Molecular biology reports · 2014Article
- Evolution at two levels of gene expression in yeast.Genome research · 2014Article
- Neutral genomic regions refine models of recent rapid human population growth.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Synonymous mutations are considered to be "silent" as they do not affect protein sequence. However, different silent codons have different translation efficiency (TE), which raises the question to what extent such mutations are really neutral. We perform the first genome-wide study of natural selection operating on TE in recent human evolution, surveying 13,798 synonymous single nucleotide polymorphisms (SNPs) in 1,198 unrelated individuals from 11 populations. We find evidence for both negative and positive selection on TE, as measured based on differentiation in allele frequencies between populations. Notably, the likelihood of an SNP to be targeted by positive or negative selection is correlated with the magnitude of its effect on the TE of the corresponding protein. Furthermore, negative selection acting against changes in TE is more marked in highly expressed genes, highly interacting proteins, complex members, and regulatory genes. It is also more common in functional regions and in the initial segments of highly expressed genes. Positive selection targeting sites with a large effect on TE is stronger in lowly interacting proteins and in regulatory genes. Similarly, essential genes are enriched for negative TE selection while underrepresented for positive TE selection. Taken together, these results point to the significant role of TE as a selective force operating in humans and hence underscore the importance of considering silent SNPs in interpreting associations with complex human diseases. Testifying to this potential, we describe two synonymous SNPs that may have clinical implications in phenylketonuria and in Best's macular dystrophy due to TE differences between alleles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.