ArticleNeurobiology of aging2012
Association of a citrate synthase missense mutation with age-related hearing loss in A/J mice.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis.Journal of the Association for Research in Otolaryngology : JARO · 2014Pooled it
- Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Citrate Synthase Knockdown Suppresses Cell Proliferation and Induces Apoptosis in Select Human Cancer Cell Lines.International journal of molecular sciences · 2025Article
- Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model.Molecular medicine (Cambridge, Mass.) · 2025Article
- Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells.Proteome science · 2022Article
- Article
- Molecular Evidence thatInternational journal of molecular sciences · 2020Article
- Age-Related Hearing Loss.Cold Spring Harbor perspectives in medicine · 2019Review
- Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity.Journal of nutrition and metabolism · 2019Article
- IGF-1 protects SH-SY5Y cells against MPPEndocrine connections · 2018Article
- Hearing Improvement in A/J Mice via the Mouse Nerve Growth Factor.Clinical and experimental otorhinolaryngology · 2017Article
- Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.PLoS genetics · 2017Article
- H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells.PloS one · 2017Article
- Anti-apoptotic treatment in mouse models of age-related hearing loss.Journal of otology · 2016Review
- Baseline Muscle Mass Is a Poor Predictor of Functional Overload-Induced Gain in the Mouse Model.Frontiers in physiology · 2016Article
- A QTL on Chr 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- New treatment options for hearing loss.Nature reviews. Drug discovery · 2015Review
- Vestibular dysfunction, altered macular structure and trait localization in A/J inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We previously mapped a locus (ahl4) on distal Chromosome 10 that contributes to the age-related hearing loss of A/J strain mice. Here, we report on a refined genetic map position for ahl4 and its association with a mutation in the citrate synthase gene (Cs). We mapped ahl4 to the distal-most 7 megabases (Mb) of chromosome 10 by analysis of a new linkage backcross and then further narrowed the interval to 5.5 Mb by analysis of 8 C57BL/6J congenic lines with different A/J-derived segments of chromosome 10. A nucleotide variant in exon 3 of Cs is the only known DNA difference within the ahl4 candidate gene interval that is unique to the A/J strain and that causes a nonsynonymous codon change. Multiple lines of evidence implicate this missense mutation (H55N) as the underlying cause of ahl4-related hearing loss, likely through its effects on mitochondrial adenosine trisphosphate (ATP) and free radical production in cochlear hair cells. The A/J mouse thus provides a new model system for in vivo studies of mitochondrial function and hearing loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.