ArticleAmerican journal of obstetrics and gynecology2011
Maternal tobacco use is associated with increased markers of oxidative stress in the placenta.
Article in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis.BMC public health · 2018Pooled it
- Article
- From Stress to Survival: Trophoblast-Derived Extracellular Vesicle Proteome Captures Aspirin-Driven Cellular Reprogramming in a Preeclampsia Model.Pharmaceutics · 2026Article
- National trends in gastroschisis factors: maternal age, smoking status, race and ethnicity.Pediatric surgery international · 2026Article
- The fetal exposome: cellular and epigenetic programming of neonatal immune function.Frontiers in immunology · 2026Review
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Research square · 2025Article
- Machine learning-enhanced surface-enhanced spectroscopic detection of polycyclic aromatic hydrocarbons in the human placenta.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered uterine artery protein signature and function following E-cigarette exposure in pregnancy.American journal of translational research · 2025Article
- Cigarette Smoke-Induced Reactive Oxygen Species Formation: A Concise Review.Antioxidants (Basel, Switzerland) · 2023Review
- Association of Placental Histology with the Pulsatility Index of Fetal and Uteroplacental Vessels during Pregnancy and with Birthweight Z-Score.Medical research archives · 2023Article
- The Effect of Tobacco Use on the Expression of Placental Transporters in Alaska Native Women.Clinical pharmacology and therapeutics · 2023Article
- Prenatal exposure to tobacco and adverse birth outcomes: effect modification by folate intake during pregnancy.Maternal health, neonatology and perinatology · 2022Article
- Article
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Validation of differential DNA methylation in newborns exposed to tobacco smoke during gestation using bisulfite pyrosequencing.microPublication biology · 2022Article
- Interactions between Environmental Exposures and the Microbiome: Implications for Fetal Programming.Current opinion in endocrine and metabolic research · 2020Article
- The impact of tobacco chemicals and nicotine on placental development.Prenatal diagnosis · 2020Review
- A novel and compact review on the role of oxidative stress in female reproduction.Reproductive biology and endocrinology : RB&E · 2018Review
- Smoking cessation in pregnancy: a continuing challenge in the United States.Therapeutic advances in drug safety · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe sought to extend our prior observations and histopathologically characterize key metabolic enzymes (CYP1A1) with markers of oxidative damage in the placental sections from smokers. STUDY
designPlacental specimens were collected from term singleton deliveries from smokers (n = 10) and nonsmokers (n = 10) and subjected to a detailed histopathological examination. To quantify the extent of oxidative damage, masked score-graded (0-6) histopathology against 4-hydroxy-2-nonenal (4-HNE) and 8-hydroxydeoxyguanisine (8-OHdG) was performed. Minimal significance (P < .05) was determined with a Fisher's exact and a 2-tailed Student t test as appropriate.
resultsWe observed a significant increase in the presence of syncytial knots in placentas from smokers (70% vs 10%, P = .02). These gross observations were accompanied by a significant aberrant placental aromatic hydrocarbon metabolism (increased CYP1A1, 4.4 vs 2.1, P = .002) in addition to evidence of oxidative damage (4-HNE 3.4 vs 1.1, P = .00005; 8-OHdG 4.9 vs 3.1, P = .0038).
conclusionWe observed a strong association between maternal tobacco use and aberrant placental metabolism, syncytial knot formation, and multiple markers of oxidative damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.