ArticleCell metabolism2011
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.
Article in Cell metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis.Endocrine reviews · 2026Review
- Epigenetic regulation of energy metabolism in obesity.Journal of molecular cell biology · 2021Review
- Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.EMBO molecular medicine · 2021Article
- Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis.Cell death & disease · 2020Article
- Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.American journal of physiology. Endocrinology and metabolism · 2019Article
- The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity.The Journal of endocrinology · 2019Article
- Maternal obesity impairs skeletal development in adult offspringThe Journal of endocrinology · 2018Article
- Long noncoding RNA myocardial infarction‑associated transcript is associated with the microRNA‑150‑5p/P300 pathway in cardiac hypertrophy.International journal of molecular medicine · 2018Article
- Managing the sugar factory: A new feather in the cap for nuclear factor Y.The Journal of biological chemistry · 2018Article
- Regulation of glucose metabolism from a liver-centric perspective.Experimental & molecular medicine · 2016Review
- Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.PloS one · 2016Article
- Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.Scientific reports · 2015Article
- Role of transcription factor acetylation in the regulation of metabolic homeostasis.Protein & cell · 2015Review
- p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways.Molecular and cellular biology · 2015Article
- Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.Frontiers in pharmacology · 2015Article
- Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.Nucleic acids research · 2014Article
- Caloric restriction mimetics: towards a molecular definition.Nature reviews. Drug discovery · 2014Review
- Article
- Energy metabolism in the liver.Comprehensive Physiology · 2014Review
- CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis.BMB reports · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Opposing activities of acetyltransferases and deacetylases help regulate energy balance. Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, but how CBP regulates energy homeostasis is unclear. In one model, the main CBP interaction with the glucagon-responsive factor CREB is not limiting for liver gluconeogenesis, whereas a second model posits that Ser436 in the CH1 (TAZ1) domain of CBP is required for insulin and the antidiabetic drug metformin to inhibit CREB-mediated liver gluconeogenesis. Here we show that conditional knockout of CBP in liver does not decrease fasting blood glucose or gluconeogenic gene expression, consistent with the first model. However, mice in which the CBP CH1 domain structure is disrupted by deleting residues 342-393 (ΔCH1) are lean and insulin sensitized, as are p300ΔCH1 mutants. CBP(ΔCH1/ΔCH1) mice remain metformin responsive. An intact CH1 domain is thus necessary for normal energy storage, but not for the blood glucose-lowering actions of insulin and metformin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.