ArticleGastrointestinal endoscopy2011
Optical biopsies by confocal endomicroscopy prevent additive endoscopic biopsies before endoscopic submucosal dissection in gastric epithelial neoplasias: a prospective, comparative study.
Article in Gastrointestinal endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01688687 (The Accuracy of Probe-based Confocal Endomicroscopy Versus Conventional Biopsies for the Diagnosis of Superficial Gastric Neoplasias), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Accuracy of Probe-based Confocal Endomicroscopy Versus Conventional Biopsies for the Diagnosis of Superficial Gastric Neoplasias
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis.BioMed research international · 2016Pooled it
- Real-time probe-based confocal laser endomicroscopy visualization of dual differentiation features in mixed-type gastric adenocarcinoma.Endoscopy international open · 2025Article
- Confocal laser endomicroscopy for gastric neoplasm.World journal of gastrointestinal endoscopy · 2024Article
- Recent advances in endoscopic management of gastric neoplasms.World journal of gastrointestinal endoscopy · 2023Review
- Review
- Article
- Application of Current Image-Enhanced Endoscopy in Gastric Diseases.Clinical endoscopy · 2021Article
- SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy.Surgical endoscopy · 2021Review
- Histological diversity and molecular characteristics in gastric cancer: relation of cancer stem cell-related molecules and receptor tyrosine kinase molecules to mixed histological type and more histological patterns.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra.Frontiers in physiology · 2020Article
- Optical biopsy in gastroenterology: Focus on confocal laser endomicroscopy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Macroscopic and microscopic fluorescence spectroscopy of colorectal benign and malignant lesions - diagnostically important features.Biomedical optics express · 2019Article
- Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis.The Journal of international medical research · 2019Article
- Feasibility of real-time intestinal bloodstream evaluation using probe-based confocal laser endomicroscopy in a porcine intestinal ischemia model.Surgical endoscopy · 2018Article
- A novel approach of optical biopsy using probe-based confocal laser endomicroscopy for peritoneal metastasis.Surgical endoscopy · 2016Article
- Article
- Endoscopic resection of early gastric cancer: current status and new approaches.Translational gastroenterology and hepatology · 2016Review
- Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions.Clinical endoscopy · 2015Review
- Ever-changing endoscopic treatment for early gastric cancer: yesterday-today-tomorrow.World journal of gastroenterology · 2014Review
- Confocal laser endomicroscopy and molecular imaging in barrett esophagus and stomach.Clinical endoscopy · 2014Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConfocal laser endomicroscopy (CLE) allows real-time in vivo histologic evaluation of GI lesions. To our knowledge, there is no reported prospective study comparing endoscopic and optical biopsy using CLE before endoscopic submucosal dissection (ESD) with post-ESD histopathology.
objectiveWe compared endoscopic and optical biopsy before ESD and thereby assessed the ability of CLE to effectively diagnose and differentiate gastric epithelial neoplasia.
designSingle tertiary-care center, prospective comparative study.
settingSoonchunhyang University Hospital, between September 2009 and April 2010. PATIENTS: This study involved 31 patients with 35 gastric epithelial neoplasias, previously diagnosed by endoscopic biopsy, who were scheduled for ESD.
interventionTarget lesions were imaged in vivo by using CLE. MAIN OUTCOME MEASUREMENTS: The overall accuracy of endoscopic and CLE diagnosis was compared with post-ESD histopathology.
resultsIn histopathology after ESD, 11 of 35 lesions (31.5%) were adenomas and 24 (68.5%) were adenocarcinomas. The overall accuracy of CLE diagnosis of gastric adenomas and adenocarcinomas was significantly higher at 94.2% (95% confidence interval [CI], 81.3-98.4), versus 85.7% (95% CI, 70.6-93.7) for endoscopic biopsy (P = .031). The overall accuracy of CLE diagnosis of differentiated and undifferentiated adenocarcinomas also was higher (95.4%; 95% CI, 78.2-99.1) than that of endoscopic biopsy (84.2%; 95% CI, 62.4-94.4) but did not differ significantly (P = .146). LIMITATIONS: Single tertiary-care center experience and small patient number.
conclusionThis study demonstrates the high accuracy of diagnosis of gastric epithelial neoplasia by using CLE. The use of CLE could possibly thus reduce the number of unnecessary biopsies and mistaken diagnoses before ESD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.