ArticleBiological psychiatry2011
Aberrant frontal lobe maturation in adolescents with fragile X syndrome is related to delayed cognitive maturation.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Public Health Literature Review of Fragile X Syndrome.Pediatrics · 2017Pooled it
- Aberrant neural activation during inhibitory control in girls with fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Article
- Frontal cortex hyperactivation and gamma desynchrony in Fragile X syndrome: Correlates of auditory hypersensitivity.PloS one · 2025Article
- Cognition, academic achievement, and adaptive behavior in school-aged girls with fragile X syndrome.Research in developmental disabilities · 2023Article
- Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice.Cell reports · 2023Article
- Brief intensive social gaze training reorganizes functional brain connectivity in boys with fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.The Journal of physiology · 2023Article
- Glucocorticoid regulation and neuroanatomy in fragile x syndrome.Journal of psychiatric research · 2021Article
- Reduced axonal caliber and structural changes in a rat model of Fragile X syndrome with a deletion of a K-Homology domain of Fmr1.Translational psychiatry · 2020Article
- Developmental studies in fragile X syndrome.Journal of neurodevelopmental disorders · 2020Review
- Building functional connectivity neuromarkers of behavioral self-regulation across children with and without Autism Spectrum Disorder.Developmental cognitive neuroscience · 2020Article
- Dysregulated Prefrontal Cortex Inhibition in Prepubescent and Adolescent Fragile X Mouse Model.Frontiers in molecular neuroscience · 2020Article
- Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Executive Function in Fragile X Syndrome: A Systematic Review.Brain sciences · 2019Review
- X-Chromosome Effects on Attention Networks: Insights from Imaging Resting-State Networks in Turner Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Functional network integration and attention skills in young children.Developmental cognitive neuroscience · 2018Article
- Basal ganglia involvement inNeuroImage. Clinical · 2018Article
- Longitudinal identification of clinically distinct neurophenotypes in young children with fragile X syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Prefrontal Cortex Dysfunction in Fragile X Mice Depends on the Continued Absence of Fragile X Mental Retardation Protein in the Adult Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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9 authors.
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Abstract
backgroundFragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period.
methodsIn this study, we examined adolescent brain development using structural magnetic resonance imaging data acquired from 59 individuals with FXS and 83 typically developing control subjects aged 9 to 22, a subset of whom were followed up longitudinally (1-5 years; typically developing: 17, FXS: 19). Regional volumes were modeled to obtain estimates of age-related change.
resultsWe found that while structures such as the caudate showed consistent volume differences from control subjects across adolescence, prefrontal cortex (PFC) gyri showed significantly aberrant maturation. Furthermore, we found that PFC-related measures of cognitive functioning followed a similarly aberrant developmental trajectory in FXS.
conclusionsOur findings suggest that aberrant maturation of the PFC during adolescence may contribute to persistent or increasing intellectual deficits in FXS.
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