ReviewExperimental cell research2011
Boundaries, junctions and transitions in the gastrointestinal tract.
Review in Experimental cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- SMURF: soft-segmentation for single-cell reconstruction and topological analysis of spatial transcriptomic data.Nature communications · 2026Article
- Boundary Formation of the Human Caudal Foregut during the Early Fetal Period: Three-Dimensional Analysis Using T1-Weighted and Diffusion Tensor Images.Cells, tissues, organs · 2026Article
- Highlights of how single-cell analyses are illuminating differentiation and disease in the gastric corpus.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.Nature cell biology · 2024Article
- Remodeling of the gastric environment inmSystems · 2024Article
- Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium.eLife · 2023Article
- Gut Microbiome Transplants and Their Health Impacts across Species.Microorganisms · 2023Review
- Tissue Engineering for Gastrointestinal and Genitourinary Tracts.International journal of molecular sciences · 2022Review
- Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer.Journal of personalized medicine · 2022Review
- Perineural invasion is a prognostic factor in stage II colorectal cancer but not a treatment indicator for traditional chemotherapy: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
- Review
- Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.Nature communications · 2021Article
- Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors.eLife · 2021Article
- Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine.Cell death and differentiation · 2021Review
- Review
- Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary.Nature · 2019Article
- Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.PLoS genetics · 2019Article
- Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- A time-resolved multi-omic atlas of the developing mouse stomach.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Contiguous regions along the mammalian gastrointestinal tract, from the esophagus to the rectum, serve distinct digestive functions. Some organs, such as the esophagus and glandular stomach or the small bowel and colon, are separated by sharp boundaries. The duodenal, jejunal and ileal segments of the small intestine, by contrast, have imprecise borders. Because human esophageal and gastric cancers frequently arise in a background of tissue metaplasia and some intestinal disorders are confined to discrete regions, it is useful to appreciate the molecular and cellular basis of boundary formation and preservation. Here we review the anatomy and determinants of boundaries and transitions in the alimentary canal with respect to tissue morphology, gene expression, and, especially, transcriptional control of epithelial identity. We discuss the evidence for established and candidate molecular mechanisms of boundary formation, including the solitary and combinatorial actions of tissue-restricted transcription factors. Although the understanding remains sparse, genetic studies in mice do provide insights into dominant mechanisms and point the way for future investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.