Evidence map›Paper›PMID 21802373›Full record

ReviewClinical lung cancer2012

Lung cancer in HIV Infection.

Deepthi Mani, Missak Haigentz, David M Aboulafia

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Clinical lung cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. A comparison of lung cancer in HIV-positive and HIV-negative populations.African journal of thoracic and critical care medicine · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.American journal of respiratory and critical care medicine · 2018
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Deepthi ManiDivision of Internal Medicine, Providence Sacred Heart Medical Center, Spokane, WA 98111, USA.
Missak Haigentz
David M Aboulafia
Montefiore Medical Center · USVirginia Mason Medical Center · US

Funding

University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 2006 to 2014
$54.7M
Paul Calabresis Career Development Award For Clinical Oncology K12CA132783 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PEREZ-SOLER, ROMAN, VERMA, AMIT K. · 2009 to 2019
$8.2M
AIDS-ASSOCIATED MALIGNANCIES CLINICAL TRIALS CONSORTIUMU01CA083118 · NCI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ABOULAFIA, DAVID M · 1999 to 2005
$487k
Depsipeptide for the Treatment of Head and Neck CancerR21CA110342 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI HAIGENTZ, MISSAK · 2005 to 2006
$443k
NCI NIH HHS K12 CA132783NCI NIH HHS R21 CA110342NCI NIH HHS U01 CA083118NCI NIH HHS U01 CA121947NCI NIH HHS U01CA121947
6 · The paper itself

Abstract

Lung cancer is the most prevalent non-AIDS-defining malignancy in the highly active antiretroviral therapy era. Smoking plays a significant role in the development of HIV-associated lung cancer, but the cancer risk is two to four times greater in HIV-infected persons than in the general population, even after adjusting for smoking intensity and duration. Lung cancer is typically diagnosed a decade or more earlier among HIV-infected persons (mean age, 46 years) compared to those without HIV infection. Adenocarcinoma is the most common histological subtype, and the majority of patients are diagnosed with locally advanced or metastatic carcinoma. Because pulmonary infections are common among HIV-infected individuals, clinicians may not suspect lung cancer in this younger patient population. Surgery with curative intent remains the treatment of choice for early-stage disease. Although there is increasing experience in using radiation and chemotherapy for HIV-infected patients who do not have surgical options, there is a need for prospective studies because this population is frequently excluded from participating in cancer trials. Evidence-based treatments for smoking-cessation with demonstrated efficacy in the general population must be routinely incorporated into the care of HIV-positive smokers.

Indexed as

HIVHIV InfectionsHumansLung NeoplasmsRisk Factors

Identifiers

PMID21802373
PMCPMC3256276
OpenAlexW2084286441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.