ArticleCurrent biology : CB2011
Regenerant Arabidopsis lineages display a distinct genome-wide spectrum of mutations conferring variant phenotypes.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 96 citations in OpenAlex.
- Genome degradation in plant tissue culture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Global characterization of somatic mutations and DNA methylation changes during vegetative propagation in strawberries.Genome research · 2024Article
- Insights into plant regeneration: cellular pathways and DNA methylation dynamics.Plant cell reports · 2024Review
- Ultra-high static magnetic field induces a change in the spectrum but not frequency of DNA spontaneous mutations inFrontiers in plant science · 2023Article
- Genomic Variation Underlying the Breeding Selection of Quinoa Varieties Longli-4 and CA3-1 in China.International journal of molecular sciences · 2022Article
- Predictable and stable epimutations induced during clonal plant propagation with embryonic transcription factor.PLoS genetics · 2022Article
- Cultivar-specific markers, mutations, and chimerisim of Cavendish banana somaclonal variants resistant to Fusarium oxysporum f. sp. cubense tropical race 4.BMC genomics · 2022Article
- miRNA Profiling and Its Role in Multi-Omics Regulatory Networks Connected with Somaclonal Variation in Cucumber (International journal of molecular sciences · 2022Article
- Somatic Mutation Analysis in Salix suchowensis Reveals Early-Segregated Cell Lineages.Molecular biology and evolution · 2021Article
- The Underlying Nature of Epigenetic Variation: Origin, Establishment, and Regulatory Function of Plant Epialleles.International journal of molecular sciences · 2021Review
- Understanding In Vitro Tissue Culture-Induced Variation Phenomenon in Microspore System.International journal of molecular sciences · 2021Review
- Androgenic-Induced Transposable Elements Dependent Sequence Variation in Barley.International journal of molecular sciences · 2021Article
- Influence of transgenesis on genome variability in cucumber lines with aPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Identification and Validation of Genetic Variations in Transgenic Chinese Cabbage Plants (Genes · 2021Article
- Datura genome reveals duplications of psychoactive alkaloid biosynthetic genes and high mutation rate following tissue culture.BMC genomics · 2021Article
- Thermal stress acceleratesGenome research · 2021Article
- Tissue culture-induced DNA methylation in crop plants: a review.Molecular biology reports · 2021Review
- Evidence for the Accumulation of Nonsynonymous Mutations and Favorable Pleiotropic Alleles During Wheat Breeding.G3 (Bethesda, Md.) · 2020Article
- Plant Genome Editing and the Relevance of Off-Target Changes.Plant physiology · 2020Article
- Genomic variation between PRSV resistant transgenic SunUp and its progenitor cultivar Sunset.BMC genomics · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
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Abstract
Multicellular organisms can be regenerated from totipotent differentiated somatic cell or nuclear founders [1-3]. Organisms regenerated from clonally related isogenic founders might a priori have been expected to be phenotypically invariant. However, clonal regenerant animals display variant phenotypes caused by defective epigenetic reprogramming of gene expression [2], and clonal regenerant plants exhibit poorly understood heritable phenotypic ("somaclonal") variation [4-7]. Here we show that somaclonal variation in regenerant Arabidopsis lineages is associated with genome-wide elevation in DNA sequence mutation rate. We also show that regenerant mutations comprise a distinctive molecular spectrum of base substitutions, insertions, and deletions that probably results from decreased DNA repair fidelity. Finally, we show that while regenerant base substitutions are a likely major genetic cause of the somaclonal variation of regenerant Arabidopsis lineages, transposon movement is unlikely to contribute substantially to that variation. We conclude that the phenotypic variation of regenerant plants, unlike that of regenerant animals, is substantially due to DNA sequence mutation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.