Trial reportJournal of feline medicine and surgery2011
Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats.
Trial report in Journal of feline medicine and surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- 2025 FelineVMA feline oral health and dental care guidelines.Journal of feline medicine and surgery · 2025Guideline
- Evaluating the safety and efficacy of equine peripheral blood-derived mesenchymal stem cells in feline chronic gingivostomatitis.Frontiers in veterinary science · 2026Trial
- Antiviral effect of poly(styrene 4-sulfonate) (PSSNa) on feline calicivirus oral infections in cats-field study.The veterinary quarterly · 2026Article
- The Biodistribution ofVeterinary sciences · 2026Article
- Combination Therapeutic Effect of Antibacterial and Antiviral Agents on Feline Chronic Gingivostomatitis Nonbounded to Prior Tooth Extraction Confirmed by Physical Signs and Clinical Biomarkers.Veterinary sciences · 2026Article
- Long-term efficacy of cyclosporine and interferon-ω in feline chronic gingivostomatitis: insights from SDAI scores.BMC veterinary research · 2025Article
- Assessment of Selected Endothelial Damage Biomarkers in the Determination of Endothelial Damage in Cats With Gingivostomatitis.Veterinary medicine and science · 2025Article
- Case Report: Xenogeneic mesenchymal stem cell secretome for the treatment of feline chronic gingivostomatitis.Frontiers in veterinary science · 2025Article
- Outbreaks of nosocomial feline calicivirus-associated virulent systemic disease in Korea.Journal of veterinary science · 2024Article
- Assessing the potential efficacy of 830-nanometer low-level laser therapy in cats: Extraoral applications.Veterinary world · 2024Article
- Epidemiological investigation of feline chronic gingivostomatitis and its relationship with oral microbiota in Xi'an, China.Frontiers in veterinary science · 2024Article
- Update on feline calicivirus: viral evolution, pathogenesis, epidemiology, prevention and control.Frontiers in microbiology · 2024Review
- Performance and overview of clinically relevant areas of application of saliva testing in the cat.Frontiers in veterinary science · 2024Review
- Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6.Scientific reports · 2023Article
- Feline chronic gingivostomatitis current concepts in clinical management.Journal of feline medicine and surgery · 2023Review
- Feline calicivirus and natural killer cells: A study of its relationship in chronic gingivostomatitis.Veterinary world · 2023Article
- Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6.Research square · 2023Article
- Prevalence of feline chronic gingivostomatitis in feral cats and its risk factors.Journal of feline medicine and surgery · 2023Article
- The Pivotal Role of Stem Cells in Veterinary Regenerative Medicine and Tissue Engineering.Veterinary sciences · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic caudal stomatitis with alveolar/buccal mucositis in calicivirus-positive cats is the most severe presentation of feline chronic gingivostomatitis. Refractory cases are helped by antibiotic and anti-inflammatory treatments often including glucocorticoids. In order to evaluate the comparative efficacy of oromucosal administration of recombinant feline interferon omega (rFeIFN-ω) versus oral administration of glucocorticoids, a randomised, multi-centre, controlled, double-blind study was performed in 39 cats. The progression of behavioural, clinical and lesional scores was assessed over 90 days. Daily oromucosal treatment with 0.1 MU of rFeIFN-ω was associated with a significant improvement of clinical lesions (caudal stomatitis and alveolar/buccal mucositis) and a decrease of pain scores from D0 to D90. Although no such statistical improvement was noticed in the prednisolone group, there was, however, no significant difference between the two groups for most of the parameters, except pain at D60 and D90.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.