ArticleChemistry & biology2011
Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate.
Article in Chemistry & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 80 citations in OpenAlex.
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- Proteases Involved in Leader Peptide Removal during RiPP Biosynthesis.ACS bio & med chem Au · 2024Review
- Staphylococcus epidermidis bacteriocin A37 kills natural competitors with a unique mechanism of action.The ISME journal · 2024Article
- Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comprehensive Approaches for the Search and Characterization of Staphylococcins.Microorganisms · 2023Article
- Improved production of class I lanthipeptides inChemical science · 2023Article
- Investigation into the mechanism of action of the antimicrobial peptide epilancin 15X.Frontiers in microbiology · 2023Article
- The structure of MadC fromFrontiers in microbiology · 2022Article
- Therapeutic Application of Lantibiotics and Other Lanthipeptides: Old and New Findings.Applied and environmental microbiology · 2021Review
- A plant endophyte Staphylococcus hominis strain MBL_AB63 produces a novel lantibiotic, homicorcin and a position one variant.Scientific reports · 2021Article
- Understanding thioamitide biosynthesis using pathway engineering and untargeted metabolomics.Chemical science · 2021Article
- Efficacy of Phage- and Bacteriocin-Based Therapies in Combatting Nosocomial MRSA Infections.Frontiers in molecular biosciences · 2021Review
- Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family.BMC genomics · 2020Article
- Multi-Omics Approaches: The Key to Improving Respiratory Health in People With Cystic Fibrosis?Frontiers in pharmacology · 2020Review
- A Structural View on the Maturation of Lanthipeptides.Frontiers in microbiology · 2020Review
- Diverse Bacteriocins Produced by Strains From the Human Milk Microbiota.Frontiers in microbiology · 2020Article
- Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- In Vitro Biosynthesis of the Nonproteinogenic Amino Acid Methoxyvinylglycine.Angewandte Chemie (International ed. in English) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Lantibiotics are ribosomally synthesized and posttranslationally modified antimicrobial peptides. The recently discovered lantibiotic epilancin 15X produced by Staphylococcus epidermidis 15X154 contains an unusual N-terminal lactate group. To understand its biosynthesis, the epilancin 15X biosynthetic gene cluster was identified. The N-terminal lactate is produced by dehydration of a serine residue in the first position of the core peptide by ElxB, followed by proteolytic removal of the leader peptide by ElxP and hydrolysis of the resulting new N-terminal dehydroalanine. The pyruvate group thus formed is reduced to lactate by an NADPH-dependent oxidoreductase designated ElxO. The enzymatic activity of ElxB, ElxP, and ElxO were investigated in vitro or in vivo and the importance of the N-terminal modification for peptide stability against bacterial aminopeptidases was assessed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.