ArticleSurgery2011
A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: management and outcomes.
Article in Surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Review of the investigation and surgical management of resectable ampullary adenocarcinoma.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2013Pooled it
- Endoscopic Papillectomy for Ampullary Tumors in Older Patients: Balancing Oncologic Benefit and Geriatric Risk.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- Predicting lymph node metastasis using preoperative parameters in patients with T1 ampulla of vater cancer.BMC cancer · 2024Article
- Article
- An ampullary adenoma presenting with jaundice caused by duodenal intussusception: a case report.Surgical case reports · 2024Article
- Controversial benefit of 5-fluorouracil/leucovorin-based adjuvant chemotherapy for ampullary cancer: a propensity score-matched analysis.Langenbeck's archives of surgery · 2022Article
- Predictors and Recurrence Patterns After Radical Surgery in Ampulla of Vater Cancer: Comparative Analysis Between Early and Late Recurrence.Frontiers in surgery · 2022Article
- Endoscopic papillectomy; a retrospective international multicenter cohort study with long-term follow-up.Surgical endoscopy · 2021Article
- Ampullary Adenocarcinoma: a Mini-Review and a Case Report of a Clinically Stable Disease Patient Treated with Herbal Supplements.Journal of gastrointestinal cancer · 2021Article
- Long-Term Outcomes of Endoscopic Papillectomy for Ampullary Adenomas.Digestive diseases and sciences · 2020Article
- Score for the Overall Survival Probability of Patients With Pancreatic Adenocarcinoma of the Body and Tail After Surgery: A Novel Nomogram-Based Risk Assessment.Frontiers in oncology · 2020Article
- Clinical outcomes of ampullary neoplasms in resected margin positive or uncertain cases after endoscopic papillectomy.World journal of gastroenterology · 2019Article
- Potential therapeutic value of primary tumor resection in ampullary cancer patients with distant metastases at initial diagnosis: a population-based study.Cancer management and research · 2019Article
- Nomograms predict long-term survival for patients with periampullary adenocarcinoma after pancreatoduodenectomy.BMC cancer · 2018Article
- Secondary tumours of the ampulla of Vater: Case report and review of the literature.Molecular and clinical oncology · 2018Article
- Overall survival and cancer-specific survival in patients with surgically resected pancreatic head adenocarcinoma: A competing risk nomogram analysis.Journal of Cancer · 2018Article
- Safety of duodenal ampullectomy for benign periampullary tumors.Annals of hepato-biliary-pancreatic surgery · 2017Article
- Can endoscopic papillectomy be curative for early ampullary adenocarcinoma of the ampulla of Vater?Surgical endoscopy · 2017Article
- Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases.Annals of surgical oncology · 2015Article
- Prognostic Value of the Metastatic Lymph Node Ratio in Patients With Resectable Carcinoma of Ampulla of Vater.Medicine · 2015Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough benign ampullary tumors are removed endoscopically, due to their potential to progress to malignant disease, the favored treatment for adenocarcinoma is pancreaticoduodenectomy. We reviewed our institution's experience in order to identify which patients were at highest risk of disease progression following surgical resection, as well as evaluate whether localized T1 tumors are best treated by pancreaticoduodenectomy.
methodsWe retrospectively reviewed 157 patients who presented with an ampullary mass, from 2001 to 2010, and identified 51 with benign adenoma and 106 with adenocarcinoma.
resultsPatients with malignant tumors most often presented with larger tumors and jaundice, which alone was predictive of survival (OR = 67). Forty-five percent of patients with pathologically confirmed T1 tumors had positive lymph nodes and median survival was modest at 60 months. Lymph node involvement was predictive of recurrence and decreased survival.
conclusionPatients with malignant tumors often present with jaundice and larger tumors. These findings should warrant suspicion for cancer and expedited preoperative workup. Based on our finding that nearly half the patients with T1 tumors had positive lymph nodes, we recommend pancreaticoduodenectomy for any patient with biopsy proven adenocarcinoma who is a suitable candidate for surgery.
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