ArticleProgress in neurobiology2011
Biomarkers and evolution in Alzheimer disease.
Article in Progress in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The Drosophila escape motor circuit shows differential vulnerability to aging linked to functional decay.PLoS biology · 2025Article
- Amyloid-Beta, Tau, and Microglial Activation in Aged Felid Brains.The Journal of comparative neurology · 2024Article
- Bearded capuchin monkeys as a model for Alzheimer's disease.Scientific reports · 2024Article
- Novel Biomarkers for Alzheimer's Disease: Plasma Neurofilament Light and Cerebrospinal Fluid.International journal of Alzheimer's disease · 2024Review
- Bearded capuchin monkey as a model for Alzheimer's disease research.Research square · 2023Article
- Article
- Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus).Acta neuropathologica communications · 2021Article
- Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans.Brain structure & function · 2020Article
- Effects of vitamin D in an animal model of Alzheimer's disease: behavioral assessment with biochemical investigation of Hippocampus and serum.Metabolic brain disease · 2020Article
- Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees.The Journal of comparative neurology · 2018Article
- Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease.Neurobiology of aging · 2017Article
- The Exceptional Vulnerability of Humans to Alzheimer's Disease.Trends in molecular medicine · 2017Review
- Frontotemporal Lobar Degeneration and MicroRNAs.Frontiers in aging neuroscience · 2016Review
- Low Cerebral Glucose Metabolism: A Potential Predictor for the Severity of Vascular Parkinsonism and Parkinson's Disease.Aging and disease · 2015Article
- The Roots of Alzheimer's Disease: Are High-Expanding Cortical Areas Preferentially Targeted?†.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Commentary: is Alzheimer's disease uniquely human?Neurobiology of aging · 2015Review
- What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus.Progress in neurobiology · 2014Review
- Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).The Journal of comparative neurology · 2013Article
- Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.Neuroscience · 2013Review
- A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls.Journal of Alzheimer's disease : JAD · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Brain regions and their highly neuroplastic long axonal connections that expanded rapidly during hominid evolution are preferentially affected by Alzheimer disease. There is no natural animal model with full disease pathology (neurofibrillary tangles and neuritic amyloid plaques of a severity seen in Alzheimer's disease brains). Biomarkers such as reduced glucose metabolism in association neocortex, defects in long white matter tracts, RNA neurochemical changes, and high CSF levels of total and phosphorylated tau protein, which are helpful to identify MCI and preclinical Alzheimer disease patients, may also provide insights into what brain changes led to this disease being introduced during hominid evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.