Evidence map›Paper›PMID 21801801›Full record

ArticleProgress in neurobiology2011

Functional biomarkers for neurodegenerative disorders based on the network paradigm.

Barry Horwitz, James B Rowe

Abstract read
In one paragraph

Article in Progress in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.Cortex; a journal devoted to the study of the nervous system and behavior · 2018
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  9. Identifying suicidal young adults.Nature human behaviour · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Barry HorwitzBrain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10, Rm. 5D39, 10 Center Drive, MSC 1402, Bethesda, MD, USA. horwitzb@nidcd.nih.gov
James B Rowe

Funding

Brain Imaging And ModelingZIADC000057 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI HORWITZ, BARRY · 2009 to 2018
$8.8M
Intramural NIH HHSMedical Research Council MC_U105597119Wellcome Trust 088324
6 · The paper itself

Abstract

This commentary provides a brief introduction to the various uses that functional neuroimaging biomarkers can play in detecting, diagnosing, assessing treatment response and investigating neurodegenerative disorders. It then goes on to explain why the emphasis of much recent work has shifted to network-based biomarkers, as opposed to those that examine individual brain regions. A number of examples are referenced that illustrate the points made.

Indexed as

Neurodegenerative DiseasesBiomarkersBrainBrain MappingHumansMagnetic Resonance ImagingNeural PathwaysPositron-Emission TomographyBiomarkers

Identifiers

PMID21801801
PMCPMC3758540

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.