ReviewVeterinary research2011
Is there a direct role for erythrocytes in the immune response?
Review in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 131 citations in OpenAlex.
- High titres of IgM-bound circulating immune complexes and erythrocytic oxidative damage are indicators of dengue severity.Clinical and experimental immunology · 2019Trial
- Manganese-Templated Nontrivial Structures for MRI and Therapy.Journal of the American Chemical Society · 2026Article
- Effects of glucocorticoid receptor activation on gene expression and antiviral responses in Atlantic salmon (Salmo salar L.) red blood cells.Veterinary research · 2025Article
- Erythrocytes as a Source of Exerkines.International journal of molecular sciences · 2025Review
- Immunomodulatory effect of CD71BMC nephrology · 2025Article
- Human and Mouse Bone Marrow CD45Biomedicines · 2025Article
- Freezing-Activated Covalent Organic Frameworks for Precise Fluorescence Cryo-Imaging of Cancer Tissue.Journal of the American Chemical Society · 2025Article
- Cell-drug conjugates.Nature biomedical engineering · 2024Review
- Transcriptomics of early responses to purifiedFrontiers in immunology · 2024Article
- Innate immune response of rainbow trout erythrocytes to spinycterins expressing a downsized viral fragment of viral haemorrhagic septicaemia virus.Aquaculture (Amsterdam, Netherlands) · 2023Article
- Immunoregulatory properties of erythroid nucleated cells induced from CD34+ progenitors from bone marrow.PloS one · 2023Article
- Farang (Molecules (Basel, Switzerland) · 2022Article
- Exploring the Phytochemical Profiles and Antioxidant, Antidiabetic, and Antihemolytic Properties ofMolecules (Basel, Switzerland) · 2022Article
- Prediction of in-hospital recurrence and false-negative results in patients with COVID-19 by red blood cell values on admission.Experimental and therapeutic medicine · 2021Article
- Article
- Transcriptionally Active Chromatin-Lessons Learned from the Chicken Erythrocyte Chromatin Fractionation.Cells · 2021Review
- Nucleic Acid Delivery with Red-Blood-Cell-Based Carriers.International journal of molecular sciences · 2021Review
- Article
- Understanding importance of clinical biomarkers for diagnosis of anxiety disorders using machine learning models.PloS one · 2021Article
- The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythrocytes are highly abundant circulating cells in the vertebrates, which, with the notable exception of mammals, remain nucleated throughout the entire life cycle. The major function associated with these cells is respiratory gas exchange however other functions including interaction with the immune system have been attributed to these cells. Many viral, prokaryotic and eukaryotic pathogens directly target this cell type and across the vertebrate group a significant number of related pathologies have been reported. Across the primary literature mechanisms of interaction, invasion and replication between viruses and erythrocytes have been well described however the functional response of the erythrocyte has been poorly studied. A fragmented series of reports spanning the vertebrates suggests that these cells are capable of functional responses to viral infection. In contrast, in-depth proteomic studies using human erythrocytes have strongly progressed throughout the past decade providing a rich source of information related to protein expression and potential function. Furthermore information at the gene expression level is becoming available. Here we provide a review of erythrocyte-pathogen interactions, erythrocyte functions in immunity and propose in light of recent -omics research that the nucleated erythrocytes may have a direct role in the immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.