ReviewBritish journal of clinical pharmacology2011
Applications of stable isotopes in clinical pharmacology.
Review in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07347262 (A Pilot Study Evaluating the Use of a Novel Noninvasive Breath Test to Identify Patients at Risk for Developing Gestational Diabetes), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study Evaluating the Use of a Novel Noninvasive Breath Test to Identify Patients at Risk for Developing Gestational Diabetes
Who cites it
27 citing papers in PubMed.
- A Diazo-free Equivalent of the Unsubstituted Carbyne Cation: Straightforward Synthesis of Naphthalenes and Pyridines via [Journal of the American Chemical Society · 2026Article
- MIMI: Molecular Isotope Mass Identifier for stable isotope-labeled Fourier transform ultra-high mass resolution data analysis.BMC bioinformatics · 2026Article
- Stable Isotope Labeling of Pyrimidines Using a Deconstruction-Reconstruction Strategy.Journal of the American Chemical Society · 2025Article
- Development of an LC-MS/MS Method for Quantifying Occidiofungin in Rabbit Plasma.Journal of mass spectrometry : JMS · 2025Article
- Composition of lipid nanoparticles for targeted delivery: application to mRNA therapeutics.Frontiers in pharmacology · 2024Review
- Late-Stage Isotopic Exchange of Primary Amines.Journal of the American Chemical Society · 2023Article
- Preclinical Bioavailability Assessment of a Poorly Water-Soluble Drug, HGR4113, Using a Stable Isotope Tracer.Pharmaceutics · 2023Article
- Determination of pharmacokinetics and tissue distribution of a novel lutetium-labeled PSMA-targeted ligand,Scientific reports · 2022Article
- A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold-labeled venetoclax, from chemistry to the clinic.Clinical and translational science · 2022Article
- Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies.BMC cancer · 2021Article
- Metabolomics in infectious diseases and drug discovery.Molecular omics · 2021Review
- Adsorption separation of heavier isotope gases in subnanometer carbon pores.Nature communications · 2021Article
- Distinguishing Pharmacokinetics of Marketed Nanomedicine Formulations Using a Stable Isotope Tracer Assay.ACS pharmacology & translational science · 2020Article
- Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- Expedient synthesis ofScience advances · 2019Article
- Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice.British journal of pharmacology · 2018Article
- Paper-based inkjet bioprinting to detect fluorescence resonance energy transfer for the assessment of anti-inflammatory activity.Scientific reports · 2018Article
- Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism.Mass spectrometry reviews · 2018Review
- Nitrogen isotopes provide clues to amino acid metabolism in human colorectal cancer cells.Scientific reports · 2017Article
- KineticScientific reports · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.