ReviewAnnual review of genomics and human genetics2011
RNA-Mediated Epigenetic Programming of Genome Rearrangements.
Review in Annual review of genomics and human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
- Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination.Biochemical Society transactions · 2025Review
- Genome-wide identification of ATP-binding cassette transporter B subfamily, focusing on its structure, evolution and rearrangement in ciliates.Open biology · 2023Article
- Self-empowerment of life through RNA networks, cells and viruses.F1000Research · 2023Review
- Macronuclear development in ciliates, with a focus on nuclear architecture.The Journal of eukaryotic microbiology · 2022Review
- Epigenetics as Driver of Adaptation and Diversification in Microbial Eukaryotes.Frontiers in genetics · 2021Article
- Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire.Nature reviews. Genetics · 2020Review
- Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors.Molecular ecology resources · 2019Article
- CRISPR-Cas in mobile genetic elements: counter-defence and beyond.Nature reviews. Microbiology · 2019Article
- Origins and evolution of CRISPR-Cas systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology.Biology & philosophy · 2019Article
- DNA-based memory devices for recording cellular events.Nature reviews. Genetics · 2018Review
- From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.Chemical reviews · 2018Review
- Review
- Comparative genome analysis of programmed DNA elimination in nematodes.Genome research · 2017Article
- Insights into transgenerational epigenetics from studies of ciliates.European journal of protistology · 2017Review
- Mobile Genetic Elements and Evolution of CRISPR-Cas Systems: All the Way There and Back.Genome biology and evolution · 2017Review
- Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery.Current opinion in microbiology · 2017Review
- Chromosome fusions triggered by noncoding RNA.RNA biology · 2017Article
- Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence.Biology direct · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
RNA, normally thought of as a conduit in gene expression, has a novel mode of action in ciliated protozoa. Maternal RNA templates provide both an organizing guide for DNA rearrangements and a template that can transport somatic mutations to the next generation. This opportunity for RNA-mediated genome rearrangement and DNA repair is profound in the ciliate Oxytricha, which deletes 95% of its germline genome during development in a process that severely fragments its chromosomes and then sorts and reorders the hundreds of thousands of pieces remaining. Oxytricha's somatic nuclear genome is therefore an epigenome formed through RNA templates and signals arising from the previous generation. Furthermore, this mechanism of RNA-mediated epigenetic inheritance can function across multiple generations, and the discovery of maternal template RNA molecules has revealed new biological roles for RNA and has hinted at the power of RNA molecules to sculpt genomic information in cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.