Evidence map›Paper›PMID 21800917›Full record

ArticleNano letters2011

De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly.

Brian F Lin, Rachel S Marullo, Maxwell J Robb, Daniel V Krogstad, Per Antoni, Craig J Hawker, Luis M Campos, Matthew V Tirrell

Abstract read
In one paragraph

Article in Nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Dendrimer-Fullerenol Soft-Condensed Nanoassembly.The journal of physical chemistry. C, Nanomaterials and interfaces · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian F LinDepartment of Chemistry and Biochemistry, Materials Research Laboratory, University of California, Santa Barbara, California 93106, United States.
Rachel S Marullo
Maxwell J Robb
Daniel V Krogstad
Per Antoni
Craig J Hawker
Luis M Campos
Matthew V Tirrell

Funding

Tumor Therapy/Annihilation Using a Smart NanoPlatform (SNaP)U54CA119335 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESENER, SADIK · 2005 to 2010
$21.2M
Nanotherapy for Vulnerable PlaqueU01HL080718 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, JEFFREY W · 2005 to 2009
$12.8M
NCI NIH HHS 1U54 CA119335NCI NIH HHS U54 CA119335NHLBI NIH HHS 1U01 HL080718NHLBI NIH HHS HHSN268201000046CNHLBI NIH HHS U01 HL080718
6 · The paper itself

Abstract

Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.

Indexed as

Biocompatible MaterialsBiomimeticsDendrimersHeLa CellsHumansMicellesNanospheresNanotechnologyPeptidesProteinsProtein Structure, SecondaryBiocompatible MaterialsDendrimersMicellesPeptidesProteins

Identifiers

PMID21800917
PMCPMC3223106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.