ArticleThe Journal of comparative neurology2011
Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Neural representation of cytokines by vagal sensory neurons.Nature communications · 2025Article
- Article
- Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- High-Throughput Functional Characterization of Visceral Afferents by Optical Recordings From Thoracolumbar and Lumbosacral Dorsal Root Ganglia.Frontiers in neuroscience · 2021Article
- Mediation of the Acute Stress Response by the Skeleton.Cell metabolism · 2019Article
- Optical recording reveals topological distribution of functionally classified colorectal afferent neurons in intact lumbosacral DRG.Physiological reports · 2019Article
- Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis.International journal of molecular sciences · 2019Review
- Endogenous Glutamate Excites Myenteric Calbindin Neurons by Activating Group I Metabotropic Glutamate Receptors in the Mouse Colon.Frontiers in neuroscience · 2019Article
- Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons.Journal of neurochemistry · 2018Article
- Characterization of glutamatergic neurons in the rat atrial intrinsic cardiac ganglia that project to the cardiac ventricular wall.Neuroscience · 2016Article
- Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord.Brain structure & function · 2016Article
- Review
- VGLUTs and Glutamate Synthesis-Focus on DRG Neurons and Pain.Biomolecules · 2015Review
- Distribution across tissue layers of extrinsic nerves innervating the mouse colorectum - an in vitro anterograde tracing study.Neurogastroenterology and motility · 2014Article
- VGLUTs in Peripheral Neurons and the Spinal Cord: Time for a Review.ISRN neurology · 2013Review
- Article
- Expression of vesicular glutamate transporters in sensory and autonomic neurons innervating the mouse bladder.The Journal of urology · 2013Article
- Distinct features of neurotransmitter systems in the human brain with focus on the galanin system in locus coeruleus and dorsal raphe.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
Vesicular glutamate transporters (VGLUTs) have been extensively studied in various neuronal systems, but their expression in visceral sensory and autonomic neurons remains to be analyzed in detail. Here we studied VGLUTs type 1 and 2 (VGLUT(1) and VGLUT(2) , respectively) in neurons innervating the mouse colorectum. Lumbosacral and thoracolumbar dorsal root ganglion (DRG), lumbar sympathetic chain (LSC), and major pelvic ganglion (MPG) neurons innervating the colorectum of BALB/C mice were retrogradely traced with Fast Blue, dissected, and processed for immunohistochemistry. Tissue from additional naïve mice was included. Previously characterized antibodies against VGLUT(1) , VGLUT(2) , and calcitonin gene-related peptide (CGRP) were used. Riboprobe in situ hybridization, using probes against VGLUT(1) and VGLUT(2) , was also performed. Most colorectal DRG neurons expressed VGLUT(2) and often colocalized with CGRP. A smaller percentage of neurons expressed VGLUT(1) . VGLUT(2) -immunoreactive (IR) neurons in the MPG were rare. Abundant VGLUT(2) -IR nerves were detected in all layers of the colorectum; VGLUT(1) -IR nerves were sparse. A subpopulation of myenteric plexus neurons expressed VGLUT2 protein and mRNA, but VGLUT1 mRNA was undetectable. In conclusion, we show 1) that most colorectal DRG neurons express VGLUT(2) , and to a lesser extent, VGLUT(1) ; 2) abundance of VGLUT2-IR fibers innervating colorectum; and 3) a subpopulation of myenteric plexus neurons expressing VGLUT(2). Altogether, our data suggests a role for VGLUT(2) in colorectal glutamatergic neurotransmission, potentially influencing colorectal sensitivity and motility.
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