ArticleThe Journal of comparative neurology2011
Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum.
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis.Scientific reports · 2025Article
- The Hippo effector TEAD1 regulates postnatal murine cerebellar development.Brain structure & function · 2025Article
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression.Molecular & cellular proteomics : MCP · 2025Article
- A Patient Case of Malan Syndrome Involving 19p13.2 Deletion ofJournal of clinical medicine · 2024Article
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- Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Control of neurogenic competence in mammalian hypothalamic tanycytes.Science advances · 2021Article
- Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients.Translational psychiatry · 2020Article
- Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development.Cerebellum (London, England) · 2020Article
- A simple, web-based repository for the management, access and analysis of micrographic images.Journal of molecular histology · 2019Article
- Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome.EBioMedicine · 2019Article
- NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.American journal of human genetics · 2018Article
- Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture.Developmental biology · 2018Article
- Transcriptional regulation of ependymal cell maturation within the postnatal brain.Neural development · 2018Article
- miR-210 promotes progression of endometrial carcinoma by regulating the expression of NFIX.International journal of clinical and experimental pathology · 2018Article
- Transcriptional regulation of intermediate progenitor cell generation during hippocampal development.Development (Cambridge, England) · 2016Article
- Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus.Scientific reports · 2016Article
- Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice.The Journal of comparative neurology · 2016Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Development of the cerebellum involves the coordinated proliferation, differentiation, maturation, and integration of cells from multiple neuronal and glial lineages. In rodent models, much of this occurs in the early postnatal period. However, our understanding of the molecular mechanisms that regulate this phase of cerebellar development remains incomplete. Here, we address the role of the transcription factor nuclear factor one X (NFIX), in postnatal development of the cerebellum. NFIX is expressed by progenitor cells within the external granular layer and by cerebellar granule neurons within the internal granule layer. Using NFIX⁻/⁻ mice, we demonstrate that the development of cerebellar granule neurons and Purkinje cells within the postnatal cerebellum is delayed in the absence of this transcription factor. Furthermore, the differentiation of mature glia within the cerebellum, such as Bergmann glia, is also significantly delayed in the absence of NFIX. Collectively, the expression pattern of NFIX, coupled with the delays in the differentiation of multiple cell populations of the developing cerebellum in NFIX⁻/⁻ mice, suggest a central role for NFIX in the regulation of cerebellar development, highlighting the importance of this gene for the maturation of this key structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.