Trial reportSleep & breathing = Schlaf & Atmung2012
Nasal versus oronasal continuous positive airway pressure masks for obstructive sleep apnea: a pilot investigation of pressure requirement, residual disease, and leak.
Trial report in Sleep & breathing = Schlaf & Atmung, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03458507 (Impact of the Type of Interface in Neuromuscular Patients Treated With Nocturnal Noninvasive Ventilation), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of the Type of Interface in Neuromuscular Patients Treated With Nocturnal Noninvasive Ventilation: a Randomized Crossover Trial
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- In search of a better CPAP interface: A network meta-analysis comparing nasal masks, nasal pillows and oronasal masks.Journal of sleep research · 2022Pooled it
- Treatment of Adult Obstructive Sleep Apnea With Positive Airway Pressure: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Pooled it
- What's leak got to do with it? Association of mask leak and positive airway pressure adherence from the homepap study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Trial
- Comparison of Auto- and Fixed-Continuous Positive Airway Pressure on Air Leak in Patients with Obstructive Sleep Apnea: Data from a Randomized Controlled Trial.Canadian respiratory journal · 2019Trial
- Comparing the Efficacy, Mask Leak, Patient Adherence, and Patient Preference of Three Different CPAP Interfaces to Treat Moderate-Severe Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Trial
- A Randomized Crossover Trial Comparing Autotitrating and Continuous Positive Airway Pressure in Subjects With Symptoms of Aerophagia: Effects on Compliance and Subjective Symptoms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Trial
- Nasal insufflation treatment adherence in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2015Trial
- CPAP therapy prevents increase in blood pressure after upper airway surgery for obstructive sleep apnoea.Sleep & breathing = Schlaf & Atmung · 2013Trial
- The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers.Sleep & breathing = Schlaf & Atmung · 2013Trial
- Higher effective oronasal versus nasal continuous positive airway pressure in obstructive sleep apnea: effect of mandibular stabilization.Canadian respiratory journalTrial
- Respiratory Effort-Driven Mandibular Opening as a Mechanism of Air Leak During CPAP Therapy.Annals of the American Thoracic Society · 2026Article
- Impact of Mask Type on Pharyngeal Opening Pressures During Drug-Induced Sleep Endoscopy.The Laryngoscope · 2025Article
- Recommendations for special challenges faced by technical personnel with geriatric patients in the sleep laboratory - a consensus statement.Sleep & breathing = Schlaf & Atmung · 2025Article
- Feasibility of three-dimensional facial imaging and printing for producing customised nasal masks for continuous positive airway pressure.ERJ open research · 2021Article
- Nasal versus oronasal mask in patients under auto-adjusting continuous positive airway pressure titration: a real-life study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- The Importance of Mask Selection on Continuous Positive Airway Pressure Outcomes for Obstructive Sleep Apnea. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2020Article
- Nasal vs. oronasal mask during PAP treatment: a comparative DISE study.Sleep & breathing = Schlaf & Atmung · 2020Article
- Impact of Mask Type on the Effectiveness of and Adherence to Unattended Home-Based CPAP Titration.Sleep disorders · 2019Article
- Upper airway obstruction induced by non-invasive ventilation using an oronasal interface.Sleep & breathing = Schlaf & Atmung · 2018Article
- Getting to the Root of the Matter.Annals of the American Thoracic Society · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis single-blinded, randomized, controlled pilot study aimed to investigate whether there is a difference between nasal and oronasal masks in therapeutic continuous positive airway pressure (CPAP) requirement, residual disease, or leak when treating obstructive sleep apnea (OSA) and if differences were related to measures of upper airway size.
methodsPatients with severe OSA currently using CPAP at ≥4 h/night with a nasal mask were examined (including Mallampati scale, incisal relationship, and mandibular protrusion) and then randomized to receive auto-positive airway pressure (PAP) or fixed CPAP at a manually titrated pressure for 1 week each at home, with immediate crossover. Within each week, a nasal mask and two oronasal masks were to be used for two or three nights each in random order. Data were downloaded from the device.
resultsTwelve patients completed the trial (mean ± SD AHI 59.8 ± 28.6 events/h; CPAP 11.1 ± 3.2 cmH(2)O; BMI 37.7 ± 5.0 kg/m(2)). During auto-PAP, the median 95th percentile pressure delivered with all masks was within 0.5 cmH(2)O (p > 0.05). During CPAP, median residual AHI was 0.61 (IQR = 1.18) for the nasal mask, 1.70 (IQR = 4.04) for oronasal mask 1, and 2.48 (IQR = 3.74) for oronasal mask 2 (p = 0.03). The 95th percentile leak was lowest with the nasal mask during both CPAP and auto-PAP (both p < 0.01). Differences in pressure or residual disease were not related to measures of upper airway shape or body habitus.
conclusionsIn obese OSA patients changing from a nasal to oronasal mask increased leak and residual AHI but did not affect the therapeutic pressure requirement. The findings of the current study highlight mask leak as the major difficulty in the use of oronasal masks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.