ArticlePsychopharmacology2012
The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Association of Menstrual Cycle with Fronto-Striatal Connectivity and Delay Discounting.Behavioral sciences (Basel, Switzerland) · 2025Article
- Mapping aggressive behaviors and testosterone among schizophrenia patients in acute stage.Schizophrenia (Heidelberg, Germany) · 2025Article
- Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex Differences in Psychosis: Focus on Animal Models.Current topics in behavioral neurosciences · 2023Review
- Stratification by Sex and Hormone Level When Contrasting Men and Women in Schizophrenia Trials Will Improve Personalized Treatment.Journal of personalized medicine · 2021Review
- ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.Molecular psychiatry · 2021Article
- The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders.International journal of molecular sciences · 2020Review
- Associations between estradiol and testosterone and depressive symptom scores of the Patient Health Questionnaire-9 in ovariectomized women: a population-based analysis of NHANES data.Annals of general psychiatry · 2020Article
- Article
- Sex Differences in Psychiatric Disease: A Focus on the Glutamate System.Frontiers in molecular neuroscience · 2018Review
- Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors.Neuropsychiatric disease and treatment · 2018Article
- Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice.Psychopharmacology · 2017Article
- Early Antipsychotic Treatment in Juvenile Rats Elicits Long-Term Alterations to the Dopamine Neurotransmitter System.International journal of molecular sciences · 2016Article
- Kynurenines, Gender and Neuroinflammation; Showcase Schizophrenia.Neurotoxicity research · 2016Review
- Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Gender effects on brain changes in early-onset psychosis.European child & adolescent psychiatry · 2015Article
- Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice.Psychopharmacology · 2015Article
- A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings.International journal of endocrinology · 2015Review
- Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain.Psychopharmacology · 2014Review
- Differential effects of estrogen and testosterone on auditory sensory gating in rats.Psychopharmacology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe sex steroid hormone, estrogen, may play a protective role in schizophrenia. We previously found that estrogen treatment inhibited serotonin-1A (5-HT(1A)) and dopamine D(2) receptor-mediated disruptions of prepulse inhibition (PPI), a measure of sensorimotor gating which is deficient in schizophrenia.
objectivesThe present study aimed to further explore the role of sex steroid hormones in schizophrenia. Part 1 of this study examined whether estrogen could inhibit PPI disruption induced by the N-methyl-D: -aspartate (NMDA) receptor antagonist, MK-801. Part 2 investigated whether the functionally protective effect of estrogen occurs in another animal model of schizophrenia, amphetamine-induced locomotor hyperactivity. Part 3 compared our previous PPI findings in estrogen-treated rats, to treatment with testosterone.
methodsFemale Sprague-Dawley rats were ovariectomized (OVX) or sham-operated. Some OVX rats received silastic implants filled with either a low (E20) or high dose (E100) of estradiol, or a low (T5) or high dose (T20) of testosterone, for at least 2 weeks before behavioral testing.
resultsThe disruption of PPI caused by MK-801 (0.1 mg/kg) was significantly reduced by treatment with estradiol (E20 and E100). However, estradiol treatment did not alter amphetamine-induced (0.25 and 0.5 mg/kg) locomotor hyperactivity, in terms of distance traveled, ambulation, or vertical counts. In contrast to estrogen, testosterone treatment did not affect disruption of PPI after administration of 8-OH-DPAT (0.5 mg/kg) or apomorphine (0.3 mg/kg). Testosterone treatment significantly enhanced the MK-801-induced (0.1 mg/kg) PPI disruption.
conclusionsEstrogen is functionally protective against 5-HT(1A)-, dopamine D(2)-, and NMDA receptor-induced PPI disruptions, while testosterone treatment enhances NMDA receptor-mediated PPI disruptions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.