ReviewMetallomics : integrated biometal science2011
Mechanisms of nickel toxicity in microorganisms.
Review in Metallomics : integrated biometal science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 339 citations in OpenAlex.
- Efficient removal of Ni, Al, and As from water using Micrococcus yunnanensis: batch experiments and explainable machine learning.Biodegradation · 2026Article
- Threats and Shifts in Microbial Communities of Salars Associated With Direct Lithium Extraction and Brine Reinjection.Global challenges (Hoboken, NJ) · 2026Article
- Molecular insights into the promiscuous ApThe Journal of biological chemistry · 2026Article
- Integrative Chemical and Omics Analyses Provide Insights into Pentlandite Bioleaching byInternational journal of molecular sciences · 2026Article
- Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies.Applied and environmental microbiology · 2026Article
- Bioremediation of Produced Water by a Polyextremophilic, Heavy-Metal-ResistantACS ES&T water · 2026Article
- Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.Nature chemistry · 2026Article
- Regulation of a nickel tolerance operon conserved inApplied and environmental microbiology · 2025Article
- A flow equilibrium model controlling cytoplasmic transition metal cation pools and preventing mis-metalation as exemplified for zinc homeostasis.Journal of bacteriology · 2025Review
- Antimicrobial Resistance in Oral Healthcare: A Growing Concern in Dentistry.Dentistry journal · 2025Review
- Structural investigations connect the disordered N-terminal extension of HypB to the activities of HypB and SlyD in E. coli.Protein science : a publication of the Protein Society · 2025Article
- Bacteria Under Metal Stress-Molecular Mechanisms of Metal Tolerance.International journal of molecular sciences · 2025Review
- FpnA, the Aspergillus fumigatus homolog of human ferroportin, mediates resistance to nickel, cobalt and gallium but does not function in iron homeostasis.Communications biology · 2025Article
- The Protective Effects of Taurine, a Non-essential Amino Acid, Against Metals Toxicities: A Review Article.Biological trace element research · 2025Review
- Olivine and dissolved alkalinity trigger different bacterial community shifts in water and oyster gills: insights from a mesocosm experiment.Frontiers in microbiomes · 2025Article
- Improving NiInternational journal of molecular sciences · 2024Article
- How to describe the time-dependent dissolution of engineered nanomaterials?Computational and structural biotechnology journal · 2024Article
- Nickel tolerance is channeled through C-4 methyl sterol oxidase Erg25 in the sterol biosynthesis pathway.PLoS genetics · 2024Article
- The role of metals in hypothiocyanite resistance inJournal of bacteriology · 2024Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nickel has long been known to be an important human toxicant, including having the ability to form carcinomas, but until recently nickel was believed to be an issue only to microorganisms living in nickel-rich serpentine soils or areas contaminated by industrial pollution. This assumption was overturned by the discovery of a nickel defense system (RcnR/RcnA) found in microorganisms that live in a wide range of environmental niches, suggesting that nickel homeostasis is a general biological concern. To date, the mechanisms of nickel toxicity in microorganisms and higher eukaryotes are poorly understood. In this review, we summarize nickel homeostasis processes used by microorganisms and highlight in vivo and in vitro effects of exposure to elevated concentrations of nickel. On the basis of this evidence we propose four mechanisms of nickel toxicity: (1) nickel replaces the essential metal of metalloproteins, (2) nickel binds to catalytic residues of non-metalloenzymes; (3) nickel binds outside the catalytic site of an enzyme to inhibit allosterically and (4) nickel indirectly causes oxidative stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.